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Genes ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1425
Author(s):  
Anna Grzywacz ◽  
Krzysztof Chmielowiec ◽  
Agnieszka Boroń ◽  
Monika Michałowska-Sawczyn ◽  
Jolanta Chmielowiec ◽  
...  

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factors (TFs) to DNA. As there are still many questions concerning the role of methylation in creating personality, we concentrated on searching for such associations. The research group was 100 sports male subjects (mean age = 22.88, SD = 6.35), whereas the control group included 239 healthy male volunteers matched for age (mean age = 21.69, SD = 3.39), both of European origin. The methods used in our research were as follows: DNA isolation, methylation-specific PCR, sequencing chromatophores, all conducted according to the manufacturer’s procedure. To evaluate personality traits, the NEO Five-Factor Personality Inventory (NEO-FFI) and STAI Inventory were used. We observed the existence of a statistically significant correlation for all the aspects of personality covered and CpG islands’ methylation. Nonetheless, we think that the tested group and the number of tested promotor islands in the DAT1 gene are still too small to make explicit conclusions, so it needs further profound analysis.


NIR news ◽  
2021 ◽  
pp. 096033602110466
Author(s):  
Silvia Grassi ◽  
Ernestina Casiraghi ◽  
Cristina Alamprese

This paper keeps on the series of articles aimed at presenting to the readers of NIR News the research groups active in the field of NIR spectroscopy in Italy. In detail, the activities of the Sensing Lab research group of the Department of Food, Environmental and Nutritional Sciences (University of Milan) are described.


Author(s):  
Naomi Jane Jacobs ◽  
Joseph Lindley

The Covid-19 pandemic led to a dramatic shift in the nature of work and collaboration for our design-led research group. In this paper, we describe the experimental use of the Gather Town platform for a variety of communication and collaboration activities. This alternative to standard video conferencing software uses spatial metaphors and attempts to regain some of the affordances of physical co-location such as serendipity and a sense of presence. In creating custom Gather spaces for our team, we found that it brought positive benefits to informal collaboration in work environment. For teaching and workshop facilitation, it created additional opportunities for flexible small-group working with affordances not available with traditional break-out rooms. We also report initial results of Gather being used in a conference setting not just to recreate the liminal, informal social spaces, but as a novel form of interactive paper presentation. While each of these experimental contexts showed benefits of a spatial digital context, we also highlight some of the challenges identified. Through this work, we question future implications for workplaces, knowledge sharing and the post-pandemic world. We ask whether digital tools and technologies should be used not only to attempt replication of physical spaces and practices, but also to explore new opportunities to work in profoundly different ways, that offer independent ways of being.


2021 ◽  
Vol 45 (3) ◽  
pp. 69-92
Author(s):  
Katarzyna Gierczak ◽  
Katarzyna Kobiela-Pionnier

Purpose: The paper presents early evidence from GPW Main Market-listed companies on the implementation of the InlineXBRL format and the ESEF mandate. Methodology/approach: Semi-structured, detailed interviews with GPW issuers are the basic research method used. Representatives of ten listed companies were interviewed. Results: The study indicates that InlineXBRL implementation is a challenge that involves significant human, time and financial resources. Moreover, it reveals that the only reason for XBRL implementation among Polish issuers is compliance with statutory requirements rather than other XBRL benefits. Ninety percent of respondents implemented the bolt-on approach, which enables fast compliance with statutory requirements; however, it does not support internal reporting and does not facilitate the financial reporting process. The study results are consistent with XBRL implementation evidence from American early adopters and confirm the thesis that an XBRL mandate is the main driver of XBRL dissemination. Limitations: The relatively small research group (10 companies). Originality/value: This study is the first in this field conducted in Poland, and this paper claims to be the first Polish one to name, structure and describe InlineXBRL implementa-tion options.


Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2384
Author(s):  
Valentin Pitzen ◽  
Sophia Sander ◽  
Otto Baumann ◽  
Ralph Gräf ◽  
Irene Meyer

The Dictyostelium centrosome is a nucleus-associated body with a diameter of approx. 500 nm. It contains no centrioles but consists of a cylindrical layered core structure surrounded by a microtubule-nucleating corona. At the onset of mitosis, the corona disassembles and the core structure duplicates through growth, splitting, and reorganization of the outer core layers. During the last decades our research group has characterized the majority of the 42 known centrosomal proteins. In this work we focus on the conserved, previously uncharacterized Cep192 protein. We use superresolution expansion microscopy (ExM) to show that Cep192 is a component of the outer core layers. Furthermore, ExM with centrosomal marker proteins nicely mirrored all ultrastructurally known centrosomal substructures. Furthermore, we improved the proximity-dependent biotin identification assay (BioID) by adapting the biotinylase BioID2 for expression in Dictyostelium and applying a knock-in strategy for the expression of BioID2-tagged centrosomal fusion proteins. Thus, we were able to identify various centrosomal Cep192 interaction partners, including CDK5RAP2, which was previously allocated to the inner corona structure, and several core components. Studies employing overexpression of GFP-Cep192 as well as depletion of endogenous Cep192 revealed that Cep192 is a key protein for the recruitment of corona components during centrosome biogenesis and is required to maintain a stable corona structure.


Author(s):  
Polly Livermore ◽  
Faith Gibson ◽  
Kathleen Mulligan ◽  
Lucy R Wedderburn ◽  
Liza J McCann ◽  
...  

Abstract Objectives Juvenile dermatomyositis is a rare, chronic autoimmune condition of childhood with known psychosocial implications. This study sought to establish current psychology support for children and young people across the United Kingdom with rheumatic conditions, with a specific focus on those with juvenile dermatomyositis. Methods Electronic surveys were distributed to the 15 centres that belong to the Juvenile Dermatomyositis Research Group in the United Kingdom, collecting responses from health care professionals in the fields of medicine, nursing and psychology. Results One hundred percent of professionals from medicine and nursing replied from all 15 centres. Of these, 7 (47%) did not have a named psychologist as part of their rheumatology team, despite the majority, 13 (87%) having more than 200 paediatric rheumatology patients. Of the remaining centres, hospital psychology provision varied considerably. When rating their service, only 3 (8%) out of 40 professionals scored their service as a 5, (where 1 is poor, 5 is excellent): there were wide discrepancies in these scores. Many challenges were discussed, including limited psychology provision, lack of time and difficulties of offering support across large geographical areas. Conclusion Many of the challenges discussed are applicable to other centres worldwide. Suggestions have been proposed which may help to improve the situation for children and young people with rheumatic conditions, including juvenile dermatomyositis. Based on these findings, we suggest that rheumatology teams maximise use of these data, to advocate and work towards more comprehensive psychology provision and support in their individual centres.


2021 ◽  
Vol 12 ◽  
Author(s):  
Youliang Liao ◽  
Bin Lin ◽  
Haiyan Zhou ◽  
Xi Yang

Previous studies have found that CEOs manage their firms through traditional methods such as leadership and management practices. In this study, we investigate how the parasocial relationship (PSR) between middle-level managers and CEOs affects the organizational trust and the organizational identification (OI) of middle managers. We find that the PSR between middle managers and CEOs has a positive effect on the OI of middle managers, which is mediated by the organizational trust of middle managers.Purpose: Middle managers and CEOs are the key components of a firm and are crucial to firm strategies and control systems. Middle managers play a vital role in information transmission like in the organizational hierarchy while CEOs influence low-level employees through middle managers. In this study, we investigate how the PSR between middle managers and CEOs affects organizational trust and OI.Design/Methodology: In this study, the data concerning OI, integrity perception, and organizational trust are derived from a survey conducted by the internal control research group of the China Securities Regulatory Commission (CSRC). The research group began the survey on September 5, 2014, for the firms listed in the A-share market, accounting firms with securities and future practice qualifications, and institutional investors through the accounting department of the CSRC, the Shanghai Stock Exchange, the Shenzhen Stock Exchange, and the Asset Management Association of China. The research group members surveyed 2,536 A-share firms listed on the Shanghai Stock Exchange and Shenzhen Stock Exchange. As of October 31, 2014, 2,154 sets of questionnaires with a total of 12,551 questionnaires were received, with a response rate of 84.95%. The financial and accounting data are from the China Stock Market and Accounting Research (CSMAR) database.Findings: We find that the PSR between middle managers and CEOs has a positive effect on the OI of middle managers, which is mediated by the organizational trust of middle managers. This study extends the application of the parasocial interaction (PSI) theory, organizational trust theory, and social identity theory in listed firms.Practical Implication: There are practical implications for internal relationship management, corporate governance, and performance management. CEOs should value the influence of organizational trust and improve his/her own social and work abilities on middle-level managers as the organizational trust of middle-level managers has a significant positive impact on their sense of responsibility, ethical behavior, organizational commitment, job satisfaction, and performance. CEOs should adopt various methods to influence different managers because organizational trust mediates the relationship between the PSR and OI.Originality/Value: Our study is one of the first attempts to apply the PSI theory to the corporate world. Given the dynamics of present-day markets and changing stakeholder demands, there is little insight into how this relationship affects organizational health and functioning. Much less what a PSR between CEO and middle management looks like in practice. Our study attempts to fill the gap by investigating how CEOs might come to affect middle managers through their practices and behaviors.


2021 ◽  
Author(s):  
Omar S. Abdellatif ◽  
Ali Behbehani ◽  
Mauricio Landin

The International Health Regulations (2005) are legally binding on 196 States Parties, Including all WHO Member States. The IHR aims to keep the world informed about public health risks, through committing all signatories to cooperate together in combating any future “illness or medical condition, irrespective of origin or source, that presents or could present significant harm to humans.” Under IHR, countries agreed to strengthen their public health capacities and notify the WHO of any such illness in their populations. The WHO would be the centralized body for all countries facing a health threat, with the power to declare a “public health emergency of international concern,” issue recommendations, and work with countries to tackle a crisis. Although, with the sudden and rapid spread of COVID-19 in the world, many countries varied in implementing the WHO guidelines and health recommendations. While some countries followed the WHO guidelines, others imposed travel restrictions against the WHO’s recommendations. Some refused to share their data with the organization. Others banned the export of medical equipment, even in the face of global shortages. The UN Compliance Research group will focus during the current cycle on analyzing the compliance of the WHO member states to the organizations guidelines during the COVID-19 pandemic.


2021 ◽  
Vol 7 (2) ◽  
pp. 109
Author(s):  
Veli Ozan Çakır

This study aimed to examine the factors that facilitate happiness in leisure. The research was performed according to the relational screening design, one of the scanning models. A total of 260 students, 180 male and 80 female, selected by simple random sampling method, studying at Istanbul University-Cerrahpaşa Faculty of Sport Sciences participated in the research group. In addition to the personal information form to collect data in the study, the Oxford Happiness Scale-Short Form (OHS-S) developed by Hills and Argyle (2002) and adapted into Turkish by Doğan and Çötok (2011), and the Leisure Facilitators Scale (LFS) developed by Kim et al. (2011) and adapted into Turkish by Gurbuz et al. (2015) were used as data collection tools. Considering the skewness and kurtosis values of the research data, it was accepted that the data showed a normal distribution. Moreover, t-test, ANOVA and Pearson Correlation test were used in the analysis. In this context, while no significant difference was found between the happiness of individuals according to their gender, a significant difference was determined between leisure facilitators. Moreover, a moderately significant relationship was found between leisure facilitators and happiness. As a result, personal, interpersonal and structural facilitators were identified as factors that facilitate the happiness of individuals in their leisure.


2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Songqiang Pang ◽  
Yao Song ◽  
Jinqiang Yang ◽  
Sen Li ◽  
Yaqiang He ◽  
...  

Objective. To explore the effect of etimicin sulfate combined with cefotaxime sodium and cefotaxime sodium alone in the treatment of patients with septic shock and the effect on serum inflammatory factor levels and immune function. Methods. Total of 95 patients with septic shock who were treated in our hospital from March 2018 to July 2020 were collected as the subjects of this study. Among them, 44 patients who received cefotaxime sodium treatment and were included in the control group, and 51 patients who received etimicin sulfate combined with cefotaxime sodium treatment were included in the research group. The levels of serum IL-6 (interleukin-6), PCT (procalcitonin), TNF-α (tumor necrosis factor-α), CD3+ (cluster of differentiation 3+), CD4+, CD4+/CD8+, FIB (fibrinogen), and PT (prothrombin time), APTT (activated partial thromboplastin time) time before and after treatment, and the treatment effects, mechanical ventilation time, hospitalization time, and incidence of adverse reactions between the two groups were compared. Results. The total effective rate of treatment in the research group (90.20%) was higher than the control group (72.73%) ( p < 0.05 ). After treatment, the serum levels of IL-6, PCT, and TNF-α, FIB, CD3+, CD4+, CD4+/CD8+, and PT and APTT time in the two groups of patients have improved significantly ( p < 0.05 ). Compared with the control group, the research group’s IL-6, PCT, TNF-α levels, PT, and APTT decreased more, and FIB, CD3+, CD4+, and CD4+/CD8+ levels increased more ( p < 0.05 ). The mechanical ventilation time and hospital stay of the research group were significantly shorter than the control group ( p < 0.05 ). There was no significant difference between the total incidence of adverse reactions in the research group (15.69%) and the control group (9.09%) ( p > 0.05 ). Conclusion. Compared with cefotaxime sodium alone, the treatment of etimicin sulfate combined with cefotaxime sodium is more effective in improving the coagulation function and cellular immune function of patients with septic shock, reducing the level of serum inflammatory factors, and having higher clinical treatment effective.


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