Dissolution is precise test method used for evaluating drug release of solid and semisolid dosage forms. It is the process by which a
solid solute enters a solution. For the analysis of dissolution test method development, the Reverse Phase High Performance Liquid
Chromatography is used, and it is the modern of column chromatography. In the reverse phase partition HPLC the relative polarity of
the stationary and mobile phase opposite to those in normal HPLC. The main applications of the dissolution testing include biopharmaceutical characterization of the drug product, as a tool to make sure consistent product quality and to predict in vivo drug
bioavailability. The article represents the current updates in dissolution testing methods by using Reverse Phase High Performance
Liquid Chromatography. The validation parameters explain for the analysis of sample is accuracy, precision, repeatability, detection
of limit, quantitative limit, linearity, range and robustness. Analytical method validation includes all procedure and checks required
to prove the reliability of a method for quantitative determination of concentration of an analyte or series of analyte in a given sample.
The conventional and novel pharmaceutical dosage forms and gives an insight to possible alternatives in drug dissolution testing
design. The aim of this review is to represent all the potential standardized test methods development and validation of
pharmaceutical dosage form by using RP-HPLC which are analyzed the accuracy of the dissolution sample of the dosage form.