Hydroa Vacciniforme-Like Cutaneous T-Cell Lymphoma

Hydroa vacciniforme (HV)-like cutaneous T-cell lymphoma (HVLL) is a controversial skin pathology because some cases appear as hydroa vacciniforme, whereas others progress to cutaneous T-cell lymphoma with or without angiocentricity. It is usually associated with infections of Epstein Barr viruses and NK-cell lymphomas and typically affects the pediatric population. Symptoms include facial edema, papules, vesicles, and blisters in the facial region, arms, legs, and areas exposed to sunlight that leave varioliform scars. There may be infiltration of the lips, eyelids, and nose, usually accompanied by comorbid infections and hypersensitivity to insect bites. Frequency is rare, but HVLL more commonly affects patients from South America and Asia. Its clinical management can be difficult and accompanied by a high index of malignancy, thus early diagnosis is essential for effective and timely management.

Factores determinantes de fotosensibilidad y dermatosis más frecuentes

En las enfermedades de la piel intervienen muchos factores fotosensibles y pueden llegar a causar lesiones agravantes en la epidermis, hasta causar riegos graves como el cáncer; y las altas tasas de exposición al sol, emiten una amplia cantidad de radiaciones electromagnéticas, pero las más importantes desde el punto de vista dermatológico, son las que pertenecen al espectro fotobiológico porque causan lesiones cutáneas (fotodermatosis). En general, parecen estar aumentando notablemente en los últimos años en todo el mundo, debido a la tendencia de las modificaciones ambientales provocadas por la contaminación, y ahora es uno de los principales o más consultado problema en salud pública en el mundo. Las organizaciones mundiales de la salud realizan investigaciones con el objetivo de obtener el índice UV más alto donde la ubicación geográfica es un importante determinante para la intensidad de los rayos UV, y su asociación con las enfermedades actínicas agudas de piel. Entre las dermatosis más comunes se mencionan: la urticaria solar, hydroa vacciniforme, erupción polimorfa lumínica, prurigo actínico, dermatitis actínica crónica, por lo cual se determina que la mayoría de pacientes con afecciones por dermatosis, se mantienen en constante exposición a la luz solar, provocando daño y alteración a la estructura de la epidermis, por lo que se puede encontrar una patología de tipo crónico, según el lapso de tiempo de exposición.

Hydroa vacciniforme-like lymphoproliferative disorder in Ecuadorian children: A case series

We report the clinical and histopathological features of hydroa vacciniforme-like lymphoproliferative disorder in five indigenous and Mestizo children. All the children resided at higher altitudes, experiencing maximal solar exposure. All cases presented with prurigo along with Epstein-Barr virus infection. Histopathologic examination showed an atypical, CD30 + lymphocytic infiltrate with angiocentricity in all, while three cases demonstrated panniculitis-like infiltrate.

Hydroa Vacciniforme-like Lymphoproliferative disorder in an adult invades the liver and bone marrow with clear pathological evidence: a case report and literature review

Background Hydroa Vacciniforme-like Lymphoproliferative Disorder (HV-LPD) is the name given to a group of Epstein-Barr virus (EBV)-associated diseases. It resembles hydroa vacciniforme (HV), the rarest form of photosensitivity, and is a T-cell disorder associated with an Epstein-Barr virus infection. The majority of diagnosed cases occur in East Asia and South America. It is rare in the United States and Europe. Multiple studies have revealed the clinical manifestation of an enlarged liver, but no gold standard such as pathology has yet supported this as a clinical sign of HV-LPD. Case presentation Here, we report a case of a 34-year-old Asian female with definite liver invasion. The patient had complained of a recurring facial rash for many years. The patient was admitted to the hospital because of an enlarged liver. After hospitalization, she was given an EB virus nucleic acid test. The EB virus nucleic acid test was positive, and pathological examination suggested that HV-LPD had invaded the skin, bone marrow, and liver. After being given antiviral treatment, the patient’s symptoms were mitigated. Conclusions Our case confirms the liver damage was caused by HV-LPD and the effectiveness of antiviral treatment.