The dynamics of synchronization of two-stage van der Pol generator

Results of numerical simulation of self-oscillations synchronization process in two-cascade ring generator van der Pol by harmonic signal are presented. Studies were carried out within the framework of the DT- model of the dynamic system. The model was developed on the basis of the principle of compliance within the framework of the method of slowly changing amplitudes of characteristics of a discrete system with characteristics of an analog prototype. Shortened equations for complex oscillation amplitudes in generator stages are obtained. It was found that in an autonomous system there is an effect of bistability of amplitudes. In the synchronization mode with an external harmonic signal, solutions of shortened equations made it possible to calculate amplitude-frequency and phase-frequency characteristics of synchronous oscillations. It is shown that transitions between bistable states are observed in the synchronous oscillation holding band. Differences of frequency characteristics of synchronization of classical and two-stage oscillators van der Pol were analyzed.

Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition

Synchronous oscillations in neural populations are considered being controlled by inhibitory neurons. In the granular layer of the cerebellum, two major types of cells are excitatory granular cells (GCs) and inhibitory Golgi cells (GoCs). GC spatiotemporal dynamics, as the output of the granular layer, is highly regulated by GoCs. However, there are various types of inhibition implemented by GoCs. With inputs from mossy fibers, GCs and GoCs are reciprocally connected to exhibit different network motifs of synaptic connections. From the view of GCs, feedforward inhibition is expressed as the direct input from GoCs excited by mossy fibers, whereas feedback inhibition is from GoCs via GCs themselves. In addition, there are abundant gap junctions between GoCs showing another form of inhibition. It remains unclear how these diverse copies of inhibition regulate neural population oscillation changes. Leveraging a computational model of the granular layer network, we addressed this question to examine the emergence and modulation of network oscillation using different types of inhibition. We show that at the network level, feedback inhibition is crucial to generate neural oscillation. When short-term plasticity was equipped on GoC-GC synapses, oscillations were largely diminished. Robust oscillations can only appear with additional gap junctions. Moreover, there was a substantial level of cross-frequency coupling in oscillation dynamics. Such a coupling was adjusted and strengthened by GoCs through feedback inhibition. Taken together, our results suggest that the cooperation of distinct types of GoC inhibition plays an essential role in regulating synchronous oscillations of the GC population. With GCs as the sole output of the granular network, their oscillation dynamics could potentially enhance the computational capability of downstream neurons.

Synchronization and coalescence in a dissipative two-qubit system

The possibility of detuned spins displaying synchronous oscillations in local observables is analysed in the presence of coupling, collective dissipation and incoherent pumping. We show that there exist two distinct scenarios in which synchronization can emerge, related respectively to the presence of a non-degenerate long-lived eigenmode and to the presence of a single-frequency regime. Both scenarios can arise by tuning parameters in this system, owing to the presence of coalascence. The former, known as transient synchronization, is here generalized in the presence of incoherent pumping, and is due to long-lasting coherences leading to a progressive frequency selection. On the other hand, in spite of the spins detuning, the dynamics can be governed by a single frequency. Still, we show that synchronization can be established only after a transient, when phase-locking arises. Spectral features of synchronization in these two scenarios are analysed for two-time correlations.

Localised signalling compartments in 2D coupled by a bulk diffusion field: Quorum sensing and synchronous oscillations in the well-mixed limit

We analyse oscillatory instabilities for a coupled partial-ordinary differential equation (PDE-ODE) system modelling the communication between localised spatially segregated dynamically active signalling compartments that are coupled through a passive extracellular bulk diffusion field in a bounded 2D domain. Each signalling compartment is assumed to secrete a chemical into the extracellular medium (bulk region), and it can also sense the concentration of this chemical in the region around its boundary. This feedback from the bulk region, resulting from the entire collection of cells, in turn modifies the intracellular dynamics within each cell. In the limit where the signalling compartments are circular discs with a small common radius ɛ ≪ 1 and where the bulk diffusivity is asymptotically large, a matched asymptotic analysis is used to reduce the dimensionless PDE–ODE system into a nonlinear ODE system with global coupling. For Sel’kov reaction kinetics, this ODE system for the intracellular dynamics and the spatial average of the bulk diffusion field are then used to investigate oscillatory instabilities in the dynamics of the cells that are triggered due to the global coupling. In particular, numerical bifurcation software on the ODEs is used to study the overall effect of coupling defective cells (cells that behave differently from the remaining cells) to a group of identical cells. Moreover, when the number of cells is large, the Kuramoto order parameter is computed to predict the degree of phase synchronisation of the intracellular dynamics. Quorum sensing behaviour, characterised by the onset of collective behaviour in the intracellular dynamics as the number of cells increases above a threshold, is also studied. Our analysis shows that the cell population density plays a dual role of triggering and then quenching synchronous oscillations in the intracellular dynamics.