Employing tools of combinatorial chemistry, an original methodological approach
has been developed and applied for the design and synthesis of a
small library of peptide-like compounds, prospective growth hormone (GH)
secretagogues. For this purpose seven building blocks of tBoc- and
Fmoc-protected amino acids was used. In this way, a small, tripeptoid
library on polyethylene glycolmonomethyl ether 5000 (PEG 5000) as a soluble
support was obtained. The library was screened by a new, simple system,
based on polyclonal rabbit antiserum raised against "GH secretagogue pharmacophore" of a known growth hormone secretagogue GHRP-6 (Hexarelin?) and
the most promising GH secretagogue candidate was selected.