This chapter on epilepsy reviews the epidemiology of epilepsy, including the classification of seizure types, causes of epilepsy, risks of seizure recurrence, and chances of remission, and examines the responsibility of the occupational health professional and sensible employee restrictions. It reviews primary and secondary prevention of epilepsy in the workplace and the impact of alcohol and drugs. It also considers the effect of antiepileptic drugs and other co-morbidities on work performance and special work problems, including disclosure of epilepsy, accidents, absence records, and employment practice. The chapter ends with a review of the medical services available, opportunities for sheltered work, and epilepsy support organizations, along with a brief discussion on relevant legislation and the driving licence regulations.