Hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) infections have particular implications for fitness for work. These include the impact of symptoms and disease, the transmissibility of infection in the course of specific work activities, and, in the case of HIV, vulnerability to other infections arising from immune deficiency. This chapter focuses on HBV, HCV, and HIV because these are the most common blood-borne viruses that have particular implications for work. Blood-borne viral infections can affect people of any age. In the UK, HIV infection is specifically mentioned and automatically considered as a disability, from the point of diagnosis, by the Equality Act 2010. HBV and HCV infections may also qualify as disabilities, if associated disease causes impairment. There are therefore practical, legal, and ethical issues to consider when assessing fitness for work in people with blood-borne viral infections.