Gadolinium-Based Paramagnetic Relaxation Enhancement Agent Enhances Sensitivity for NUS Multidimensional NMR-Based Metabolomics

Gadolinium is a paramagnetic relaxation enhancement (PRE) agent that accelerates the relaxation of metabolite nuclei. In this study, we noted the ability of gadolinium to improve the sensitivity of two-dimensional, non-uniform sampled NMR spectral data collected from metabolomics samples. In time-equivalent experiments, the addition of gadolinium increased the mean signal intensity measurement and the signal-to-noise ratio for metabolite resonances in both standard and plasma samples. Gadolinium led to highly linear intensity measurements that correlated with metabolite concentrations. In the presence of gadolinium, we were able to detect a broad array of metabolites with a lower limit of detection and quantification in the low micromolar range. We also observed an increase in the repeatability of intensity measurements upon the addition of gadolinium. The results of this study suggest that the addition of a gadolinium-based PRE agent to metabolite samples can improve NMR-based metabolomics.

TD-SCDMA Smart Antenna Signal Intensity Measurement System

With the rapid development of China's TD-SCDMA system, how to qualitative and quantitative to judge intelligent antenna electromagnetic radiation pollution is a problem to be solved. Due to the special working principle of smart antenna, the second generation communication system spectrometer and field intensity meter measurement method is a complicated and difficult to operate. This paper introduces a design suitable for TD smart antenna measurement system: this system can realize in single user or multiple users at the same time and the TD base station set up calls link of multi-point synchronous signal intensity measurement. The measurement results of our system are very close to the measurement results of spectrometer field intensitys and can reasonable reflect TD stations around the extent of the electromagnetic radiation. This method of our system is easy, cheap and maneuverable