Appropriate drinking water defluoridation technology is urgently needed in china, which has a wide fluoride-rich area. The adsorption defluoridation method in the industrial high fluoride wastewater treatment is generally considered to be efficient and economic. However, the practical application of the method is not ideal in obtaining drinking water defluoridation. Four representative adsorbents activated alumina, activated zeolite, hydroxyapatite and hydrous zirconium oxide have been tested in terms of defluoridation efficiency under natural high fluoride groundwater and compared to clarify existing problems of adsorption methods. Results show that pH significantly affected adsorption efficiency. The adsorbents have low adsorption capacity under natural high fluoride groundwater and can achieve good adsorption effect under acidic conditions. However, in adjusting the water to the appropriate pH range, the adsorption method loses its advantages of convenience and affordability. Therefore, any adsorbent should be tested with actual field waters before designing filed application systems. Further research is also warranted in evaluating the field performance and the economic acceptance of the proposed method.