Cyclohexane Oxidation in the Presence of Cobalt Chelates

Influence of individual compounds with innercomplex properties in the liquid phase cyclohexane oxidation process has been considered.

An Evaluation of the Tumour Affinity of the Radioactive Cobalt Chelate of Tallysomycin S10b in Lymphoma-Bearing Mice

The tumour affinity of the radioactive cobalt chelate of tallysomycin S10b (Tim S-10b). a promising structural analogue of Bleomycin, was assessed using a mouse lymphoma model. The highest concentrations (%dose/gram tissue) were observed in the kidneys, followed by the tumour (4.1 %/g 1 h p.i.) at 1 h, 4 h and 48 h. The tumour had the highest concentration among all tissues at 24 h. The biodistribution profile of 60Co-Tlm S10b was distinctly different from that obtained with 60CoCl2, demonstrating the in vivo stability of the chelate. More than half of the chelate (56.8% of the injected dose) was excreted in the urine at 1 h. The highest tumour/non-tumour ratios were obtained for blood (41.3, 4 h), bone (30.5, 4 h) and muscle (29.2, 48 h). Scintigraphy at 24 h, using 57Co-Tlm S10b, showed the tumour, liver, kidney and bladder clearly. The similarities and differences exhibited by Co-Tim S10b with reference to the literature on cobalt chelates of Bleomycin and naturally occurring tallysomycin (A + B) are discussed.