The majority of people with intellectual disabilities live with family members, and those people who live elsewhere usually very much value contact with family members. Therefore, nurses who work with people with intellectual disabilities need to have a clear understanding of families and collaborative working. This chapter explores the definition of families, the impact that having a person with intellectual disabilities as a family member may have, and how this can change the life cycle of a family as families adapt to their changing circumstances. It also explores collaborative working with family members, parents with intellectual disabilities, parents of people with intellectual disabilities and siblings, as well as looking at family quality of life and social, cultural, and spiritual factors that may need to be considered.