enzymes of antioxidant defense
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2016 ◽  
Vol 18 (2(66)) ◽  
pp. 96-100
Author(s):  
O.V. Kuljaba ◽  
V.V. Stybel ◽  
B.V. Gutyj

The article deals with the results of researches of fasciolosis and myco bacteriosis on the activity of enzymatic antioxidant system level and the level of lipid peroxidation products.Fasciola and mycobacteria inhibit the activity of enzymes of antioxidant defense system  in the liver hosts, as indicated by decreased activity of catolase by 23%, superoxide dismutase by 35% and increase of lipid hydroperoxides level by 43% (p < 0.001), TBA-products by 23% (p < 0.001) compared with healthy animals.The use of clozaverm A and catozale by research cows promotes the reducing of HPL and TBA- active products in their blood, preventing the development of oxidative stress. Thus, the use of clozaverm A and catozale by animal from the research groups contributed to rapid increase of catolase activity, beginning with the 7th day of the experiment. At the 21st and 28th day of experiment the activity of investigated enzyme varies within the limits of physiological values. At the same time in a certain relationship with the intensity of redox processes in the tissues of animals is SOD activity. At the 21st  day of the experiment enzyme activity in experimental group D2 was increased by 34% compared to the control group.The analysis of the obtained results indicates that superoxide dismutase activity in serum of cows of the research groups has positively correlated  action with the activity of catolase.After application of clozaverm A for the treatment of cows by the experimental fasciolosis, sensitized atypical mycobacteria, is set the decrease in the intensity of lipid per oxidation at the 14th  day of the experiment HPL by 11%, and the level of TBA-active products, respectively, by 9% compared to control.The inhibition of lipid per oxidation for treatment of animal with drugs «Clozaverm A» and «Catozal» caused by activation of metabolic processes in the organism, which involve enzymes, including enzymes and antioxidants that catalyze oxidation and phosphorylation, and also by strengthening erytro poetical  function of bone marrow.


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