The establishment of stands from directly sown seed may be a way to reduce the current high costs associated with guayule (Parthenium argentatum Gray) cultivation. These field studies were conducted to examine the combined effects of shade and fungicides on the survival of guayule seedlings established from directly sown seed. Soil in the experimental plot was a loam of pH 7.25. The following fungicides: a) Terraclor Super X, b) Ridomil 5G, c) Ridomil PC llG, d) Tilt 3.6E, e) Terracoat, and f) Vitavax + PCNB were tested alone and in combination with the nonwoven polyester shadecloth, Reemay, to identify treatments enhancing seed germination and seedling establishment. In all cases, seedling emergence in microplots covered with Reemay was significantly higher than in noncovered microplots. Terraclor Super X, Ridomil 5G, and Ridomil PC 1 lG were effective only when used in combination with the shadecloth. The long-term survival of guayule seedlings was strongly affected by severe climatic events. Since Reemay-protected seedlings were larger and more robust, they were more likely to survive the climatic extremes than unprotected seedlings. Two new guayule seedling pathogens were recorded -pythium dissotocum Drechsler and P. paroecandrum Drechsler. Chemical names used: 5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole (Terrazole) + pen. tachloronitrobenzene (PCNB); N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-alamine methyl ester Ridomil + PCNB; 7. bromo-5-chloro-quinolin-8-yl-acrylate; Terrazole 5,6-dihydro-2-methyl-l,4 -oxathiin-3-carboxanilide + PCNB.