The Influence of Fermented Mare’s Milk Processing Under Pressure of Gaseous Nitrogen on the Quality of Koumiss

The urgency of the problem of increasing the nutritional qualities of mare's milk is that, it has versatile uses. Many people traditionally prefer koumiss made of milk with high fat content, as it has good taste, mouth-watering appearance, high calorie content, helps to increase liver weight. In many patients, including tuberculosis, hypotrophic and malnourished due to a long and serious illness, the latter aspect is an important part of treatment. In the production of raw materials for baby and diet food, first of all, it is necessary to achieve an increase in the protein and fat content of mares, as well as to stabilize the content of valuable components in milk during lactation. Therefore, the search for methods for correcting the composition of dairy raw materials is relevant to industry issues. This article presents the results on the research of influence of Hydro mechanical processing on the physicochemical and microbiological properties of mare's milk. Milk processing treatment by gaseous nitrogen was carried out at laboratory-patented system. This method has not had a negative impact on its physical and chemical characteristics, but significantly increased the bactericidal life. The introduction of pure cultures of koumiss leaven in processed and not processed raw milk has reduced the acidity build-up to the optimal value allowing increase in the life of koumiss.

Biochemical effects of the porphyrinogenic drug allylisopropylacetamide. A comparative study with phenobarbital

Successive administrations of allylisopropylacetamide, a potent porphyrinogenic drug, increase liver weight, microsomal protein and phospholipid contents. There is an increase in the rate of microsomal protein synthesis in vivo and in vitro. The drug decreases microsomal ribonuclease activity and increases NADPH–cytochrome c reductase activity. Phenobarbital, which has been reported to exhibit all these changes mentioned, is a weaker inducer of δ-aminolaevulinate synthetase and increases the rate of haem synthesis only after a considerable time-lag in fed female rats, when compared with the effects observed with allylisopropylacetamide. Again, phenobarbital does not share the property of allylisopropylacetamide in causing an initial decrease in cytochrome P-450 content. Haematin does not counteract most of the biochemical effects caused by allylisopropylacetamide, although it is quite effective in the case of phenobarbital. Haematin does not inhibit the uptake of [2-14C]allylisopropylacetamide by any of the liver subcellular fractions.

Effect of Spironolactone and Ethylestrenol on Benzo(a)pyrene Hydroxylase (EC 1.14.1.1) and Other Chemical Constituents of Hepatic Microsomes

In rats, spironolactone and ethylestrenol, like phenobarbital, enhance the NADPH-dependent hydroxylation of benzo(a)pyrene in the hepatic microsomal plus supernatant fraction and increase liver weight and microsomal phospholipid content as well as NADPH cytochrome c reductase and diaphorase activities, but only ethylestrenol and phenobarbital influence the microsomal protein content and cytochrome P-450 level.Neither spironolactone, ethylestrenol, nor phenobarbital affects NADH cytochrome c reductase and diaphorase activities, and only phenobarbital alters the cytochrome b5 level.These findings indicate that, while both the steroids and phenobarbital stimulate microsomal mixed-function oxidation, there are qualitative and quantitative differences between their action.