Introduction: There is no specific treatment and vaccine for COVID-19 yet. The prospective vaccine is the
primary prevention and is the promising preventive strategy to gain herd immunity. The study aimed to
identify COVID-19 vaccine acceptance rate among primary health care attendees at Durban, South Africa.
Method: A questionnaire based cross-sectional study was conducted at the Kwadabeka Community Health
Centre, Durban, South Africa. Chi-square test and logistic regression were carried out to identify the factors
for COVID-19 vaccine acceptability. P-values <0.05 were reported and considered statistically significant.
Results: Almost two-thirds (61.4%) of the participants reported that they would accept a COVID-19
vaccine. Logistic regression analysis found that respondents’ attitude on whether “COVID-19 pandemic
will be dealt with successfully” was 2.3 times more likely to accept the vaccine (OR=2.3, 95% CI: 1.3-3.8,
p<0.05) and good practice on “use of a face mask to public places were 3 times more likely to accept the
vaccine (OR=3.0, 95% CI: 1.5-6.1, P<0.05). On the contrary, knowledge on “only elderly people die from
COVID-19 (False)” revealed that 44% were less likely to accept the vaccine (OR=0.56, 95% CI: 0.33-0.95,
P<0.05) and practice on social distance “keep a distance of 1-2 m in public places” was 69% less likely to
accept the vaccine (OR=0.31, 95% CI: 0.15-0.63, p<0.05).
Conclusion: The COVID-19 vaccine acceptance rate is comparable with other studies. However,
community-based studies and a mass educational and communication campaign to promote the COVID-19
vaccination coverage to the general population are recommended.