This chapter traces the history of Arab medicine and science and how Greek, Indian, and Persian medical knowledge had come to Arab medical practices. It considers the Arab attitude to science, the translation of Greek science into Arabic, as well as the assimilation of theoretical and practical medicine into Arab culture. Hereafter the chapter considers the influences of Persian and Indian medicines in Arab culture, and how Baghdad acted as the hub and crossroads through which diverse intercultural medical legacies passed: those of the Greek, Indian, Persian, and the local Mesopotamian. Finally, the chapter turns to the trends and distribution of medicinal substances and other products that emerged from the Islamic conquests from the seventh to eighth centuries — a process that persisted through to the tenth to twelfth centuries and even later.