Soon after the Santuario’s construction was completed in 1816, Spain was defeated in Mexico’s war for independence (1821). In 1847 the regime once again changed, with the arrival and takeover by the Americans during the Mexican-American War. This chapter shows how New Mexican Catholics, especially in and around Chimayó, adapted to the changes in both political and ecclesiastical oversight that occurred in these tumultuous decades. Other topics are the 1837 Chimayó Rebellion; the difficulties and conflicts that resulted from Archbishop Jean Baptiste Lamy’s tenure; and the challenge by Padre Antonio José Martínez and other local Hispano leaders to the new order imposed by Archbishop Lamy.