Papular-Purpuric 'Gloves and Socks' Syndrome Associated With Human Herpesvirus 6 Infection

Background and Objective: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis that can be limited to the skin but may also affect other organs. Often, its cause is unknown. LCV has previously been reported to occur with the reactivation of human herpesvirus 6 (HHV-6). Here, we report a second instance of HHV-6 reactivation in a 43-year-old woman with idiopathic cutaneous LCV. </P><P> Case Description: In this case, the patient was immunocompetent, and testing revealed that she had inherited chromosomally integrated human herpesvirus 6 variant A (iciHHV6-A) with a parallel skin infection of HHV-6B. The integrated ciHHV-6A strain was found to be transcriptionally active in the blood, while HHV-6B late antigen was detected in a skin biopsy. The patient’s rash was not accompanied by fever nor systemic symptoms and resolved over four weeks without any therapeutic intervention.Conclusion:In light of the transcriptional activity documented in our case, further examination of a possible role for HHV-6 in the etiology of LCV is warranted.

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Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus.

Journal of Virology ◽

10.1128/jvi.63.7.3161-3163.1989 ◽

1989 ◽

Vol 63 (7) ◽

pp. 3161-3163 ◽

Cited By ~ 191

Author(s):

K Takahashi ◽

S Sonoda ◽

K Higashi ◽

T Kondo ◽

H Takahashi ◽

...

Keyword(s):

T Lymphocyte ◽

Human Herpesvirus ◽

Human Herpesvirus 6 ◽

Related Virus ◽

Herpesvirus 6

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51: Detection of human herpesvirus-6 (HHV-6) genomes by in situ PCR and in situ hybridization in tissues from Kawasaki disease and in coronary arteries of transplanted hearts

Journal of Clinical Virology ◽

10.1016/s1386-6532(06)70070-1 ◽

2006 ◽

Vol 37 ◽

pp. S111 ◽

Cited By ~ 1

Author(s):

J. Luka ◽

C. Afflerbach ◽

S.D. Carson ◽

G.F. Kraeger

Keyword(s):

In Situ Hybridization ◽

Kawasaki Disease ◽

Coronary Arteries ◽

Human Herpesvirus ◽

Human Herpesvirus 6 ◽

In Situ Pcr ◽

Herpesvirus 6 ◽

Transplanted Hearts

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Hemolytic uremic syndrome related to Shiga-like toxin-producing Escherichia coli with encephalitis hiding a human herpesvirus-6 infection: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02873-8 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Sophie Mounier ◽

Arthur Gavotto ◽

Julie Tenenbaum ◽

Pierre Meyer ◽

Marc Fila ◽

...

Keyword(s):

Escherichia Coli ◽

Pericardial Effusion ◽

Hemolytic Uremic Syndrome ◽

Central Nervous System Involvement ◽

Human Herpesvirus ◽

Neurological Involvement ◽

Stool Examination ◽

Human Herpesvirus 6 ◽

Uremic Syndrome ◽

Herpesvirus 6

Abstract Background Cardiac and neurological involvement in hemolytic uremic syndrome are life-threatening complications. The most frequent complications of cardiac involvement in hemolytic uremic syndrome are myocarditis and cardiac dysfunction due to fluid overload. Pericarditis remains very rare in hemolytic uremic syndrome. To our knowledge, only five cases of cardiac tamponade associated with hemolytic uremic syndrome have been described in literature. Case summary A 27-month-old Caucasian girl presented with symptoms of nonbloody diarrhea and tonic-clonic seizures. The diagnosis of Shiga-like toxin-producing Escherichia coli hemolytic uremic syndrome with central nervous system involvement was made, and stool examination revealed infection with a Shiga-like toxin-producing Escherichia coli. She did not need renal replacement therapy but had severe neurological impairment. The patient’s course was complicated by pericardial effusion. A pericardiocentesis was performed via an apical approach because the pericardial effusion was predominantly surrounding the left ventricle. Effusion analysis showed an exudate and positivity for human herpesvirus-6B on polymerase chain reaction with viremia. This finding was consistent with primary human herpesvirus-6 infection with encephalitis. Conclusion We report this uncommon case of Shiga-like toxin-producing Escherichia coli hemolytic uremic syndrome associated with a severe human herpesvirus-6 infection. Secondary isolated pericardial effusion and atypical neurological involvement are uncommon in Shiga-like toxin-producing Escherichia coli hemolytic uremic syndrome and should lead the physician to perform additional investigations.

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