Clinical course and complications in Hodgkin's disease

1973 ◽  
Vol 131 (3) ◽  
pp. 332-353 ◽  
Author(s):  
J. E. Ultmann
1995 ◽  
Vol 20 (1-2) ◽  
pp. 59-65 ◽  
Author(s):  
Mary Varterasian ◽  
Voravit Ratanatharathorn ◽  
Joseph P. Uberti ◽  
Chatchada Karanes ◽  
Esteban Abella ◽  
...  

Cancer ◽  
1974 ◽  
Vol 33 (4) ◽  
pp. 1123-1126 ◽  
Author(s):  
Ralph E. Johnson ◽  
Louis B. Thomas ◽  
Sandra K. Johnson ◽  
Gerald S. Johnston

1992 ◽  
Vol 51 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Paul H. Levine ◽  
Peter Ebbesen ◽  
Dharam V. Ablashi ◽  
W. Carl Saxinger ◽  
Axel Nordentoft ◽  
...  

1989 ◽  
Vol 75 (6) ◽  
pp. 637-639
Author(s):  
Lia Ginaldi ◽  
Lanfranco Venturoni ◽  
Girolamo Cretara ◽  
Dennis Quaglino

The authors describe a case of nodular-sclerosing Hodgkin's disease, originally observed in clinical stage III B and treated by systemic chemotherapy, with relapse after a 28-year disease-free interval. As far as we know, the length of remission in this case is second only to that of a case recently described by Hung and coworkers. Therefore, although according to data in the literature relapse after a very long disease-free interval is more frequently observed in patients with stage I A and II A disease, it may occur also in cases with symptomatic, widespread disease. This phenomenon, while reflecting the complexity of relations between the different factors (histologic subtype, clinical stage, host vs tumor defenses, therapy, etc.) that variously affect the clinical course and outcome, underlines the need for cautiousness when assessing the ultimate prognosis of individual cases of Hodgkin's disease.


2005 ◽  
Vol 16 (5) ◽  
pp. 793-797 ◽  
Author(s):  
P. Das ◽  
A.K. Ng ◽  
M.A. Stevenson ◽  
P.M. Mauch

1991 ◽  
Vol 9 (6) ◽  
pp. 947-953 ◽  
Author(s):  
V F Guinee ◽  
G G Giacco ◽  
M Durand ◽  
J W van den Blink ◽  
A Gustavsson ◽  
...  

This investigation was undertaken to assess the apparent poor survival of older patients with Hodgkin's disease. The clinical course of Hodgkin's disease in 136 patients, 60 to 79 years of age, was compared with that of 223 patients, 40 to 59 years of age. The patients registered from November 1977 through December 1983 had not been previously treated, and were treated at eight cancer centers. When the prognosis of all patients was examined by age, a definite change in the pattern of survival first appeared in the 60- to 69-year-old cohort. The entire older group (60 to 79 years) experienced twice the risk of dying from Hodgkin's disease and four times the risk of dying from other causes than did the younger group. In both groups, stage of disease was the strongest factor in predicting adjusted survival. Delay in treatment and advanced stage at presentation were not characteristic of Hodgkin's disease in older patients as has been postulated. Older patients responded to therapy with a similar complete remission rate (84% v 88% in the younger group, P = .24). From this study, we conclude that (1) Hodgkin's disease in the older adult does not have a different natural history, its major risk factors are similar to those known in other age groups, and thus should be amenable to existing therapeutic approaches; and (2) the prognosis of older patients with Hodgkin's disease has been obscured in previous studies by the inclusion of deaths due to other causes in survival estimates.


Blood ◽  
1972 ◽  
Vol 39 (5) ◽  
pp. 595-601 ◽  
Author(s):  
Michael P. Corder ◽  
Robert C. Young ◽  
Robert S. Brown ◽  
Vincent T. DeVita

Abstract Forty-three untreated patients with Hodgkin’s disease were evaluated between 1965 and 1967 with PHA-stimulated peripheral leukocyte cultures. No correlation was found between PHA-induced lymphocyte transformation at the time of diagnosis and the clinical course of the patient’s Hodgkin’s disease. There is also no correlation between lymphocyte transformation and the histologic pattern of nodular sclerosis. Although PHA-induced lymphocyte transformation appears to be a general index of immunologic status, it has not proven of value as a prognostic sign in Hodgkin’s disease.


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