MB-Creatine Phosphokinase Isoenzyme Elevation Not Diagnostic of Myocardial Infarction

1977 ◽  
Vol 137 (8) ◽  
pp. 1089 ◽  
Author(s):  
B. T. Adornato
Keyword(s):  
Myocardial Infarction ◽  
Creatine Phosphokinase

ASSESSMENT OF BIOCHEMICAL PARAMETERS IN DIABETIC AND NON-DIABETIC ACUTE MYOCARDIAL INFARCTION PATIENTS

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Darshna Jain
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Creatine Phosphokinase ◽  
Density Lipoprotein ◽  
Normal Blood ◽  
Cardiac Markers

Background: The present study was design to assess the level of altered lipid profile, lipoprotein sub fractions, oxidative stress and antioxidants in coronary artery disease with type-2 diabetes mellitus’s patients and non diabetic patients. Methods: This case–control study included 300 subjects; out of which, 100 subjects were with normal blood glucose level and with normal ECG (Normal, N), 100 subjects  were with normal blood glucose level and AMI (non-diabetic and AMI, N-AMI) and 100 subjects were with diabetes and AMI (Diabetic and AMI, D-AMI) Results: D-AMI individuals had high level of total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), and low level of high density lipoprotein (HDL) in comparison to N-AMI individuals. The cardiac markers such as Troponin I, creatine phosphokinase (CPK), creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and C-reactive protein (CRP) levels were significantly increased in patients suffering from myocardial infarction with diabetes mellitus (DM) compared to patients of myocardial infarction without DM. The antioxidant superoxide dismutase (SOD) and glutathione (GSH) were lower in D-AMI patients than in N-AMI. However, levels of malondialdehyde (MDA) and catalase (CAT) were higher in D-AMI than in N-AMI controls. Conclusion: Our study suggested that patients with D-AMI have elevated cardiac markers and reduced antioxidants levels as compared to N-AMI patient. Keywords: Diabetes Mellitus, Acute Myocardial Infarction, Creatine Phosphokinase, Glutathione

Creatine Phosphokinase Activity in Myocardial Infarction, Heart Failure, and Following Various Diagnostic and Therapeutic Procedures

1968 ◽  
Vol 14 (12) ◽  
pp. 1185-1196 ◽  
Author(s):  
Leonard V Crowley
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Electroconvulsive Therapy ◽  
Cardiac Failure ◽  
Creatine Phosphokinase ◽  
Coronary Arteriography ◽  
Surgical Operation ◽  
Patients With Heart Failure ◽  
Therapeutic Procedures ◽  
Infarction Heart

Abstract The creatine phosphokinase(CPK) test based on the method of Okinaka et al. (1) was compared with the glutamic oxalacetic transaminase (GOT) test of Reitman and Frankel (2) in patients with myocardial infarction, cardiac failure, and following various diagnostic and therapeutic procedures. The CPK method used was somewhat less discriminatory than the GOT method in detecting myocardial infarction. The CPK test possessed greater specificity, since it was not elevated in congestive cardiac failure, while the GOT test was elevated in 25% of the patients with heart failure. Therefore, the CPK test offered a real advantage when evaluating suspected infarction in the presence of cardiac failure. CPK activity may be elevated when the GOT test is normal, indicating the advantage of performing more than one enzyme procedure in suspected myocardial infarction. Both GOT and CPK were elevated in many patients following surgical operation and cardiac catheterization. No CPK elevations were encountered after electroconvulsive therapy, and CPK was only occasionally elevated following coronary arteriography.

A Study of the Problems of Inactivation of Creatine Kinase in Serum

1972 ◽  
Vol 18 (4) ◽  
pp. 330-334 ◽  
Author(s):  
Fram R Dalal ◽  
Jonathan Cilley ◽  
Seymour Winsten
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Room Temperature ◽  
Creatine Phosphokinase ◽  
Serum Creatine Kinase ◽  
Sulfhydryl Groups ◽  
The Other ◽  
Clinical Pattern

Abstract Addition of sulfhydryl groups to the reaction mixture, to stabilize serum creatine kinase (creatine phosphokinase, CPK), results in apparent increases in the activity of this enzyme in many sera. In addition, in sera from patients just after myocardial infarction, assays for sulfhydryl-activated CPK have a different clinical pattern than do those for CPK assayed without sulfhydryl activators: activities are greater and remain abnormally high longer in assays in which the enzyme is sulfhydryl activated. If the assay is done without sulfhydryl activators present, technical difficulties appear, because CPK in serum is rapidly inactivated at room temperature. CPK is apparently inactivated in at least two ways. One, which is irreversible, is inhibited by albumin; the other, which is reversible by sulfhydryl groups, seems to result from the presence of substances in the pooled serum used that are both protein bound and free.

scholarly journals Persistence of MB isoenzyme of creatine phosphokinase in the serum after minor iatrogenic cardiac trauma. Absence of postmortem evidence of myocardial infarction.

Circulation ◽  
1975 ◽  
Vol 51 (4) ◽  
pp. 627-627 ◽  
Author(s):  
A M Tonkin ◽  
R M Lester ◽  
C E Guthrow ◽  
C R Roe ◽  
D B Hackel ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Creatine Phosphokinase ◽  
Cardiac Trauma
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