Use of Centrally Acting Sympatholytic Agents in the Management of Hypertension

1991 ◽  
Vol 151 (8) ◽  
pp. 1638 ◽  
Author(s):  
James R. Oster
Keyword(s):  
Sympatholytic Agents

Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?

2015 ◽  
Vol 130 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Giovanni Sansoè ◽  
Manuela Aragno ◽  
Raffaella Mastrocola ◽  
Maurizio Parola
Keyword(s):  
Antidiuretic Hormone ◽  
Water Retention ◽  
Renal Excretion ◽  
Free Water ◽  
Experimental Cirrhosis ◽  
Advanced Cirrhosis ◽  
Adrenoceptor Agonists ◽  
Sympatholytic Agents ◽  
Dilutional Hyponatraemia

Adrenergic hyper-function reduces renal excretion of water. In advanced cirrhosis, hypersecretion of vasopressin (antidiuretic hormone or ADH) is considered the cause of dilutional hyponatraemia. We show that in experimental cirrhosis sympatholytic agents (α2A-adrenoceptor agonists) are as effective as V2 antagonists to blunt water retention.

Effect of Sympathetic Blocking Agents on the Toxic Action of O2 at High Pressure

1957 ◽  
Vol 188 (3) ◽  
pp. 593-598 ◽  
Author(s):  
Paul C. Johnson ◽  
John W. Bean
Keyword(s):  
Significant Degree ◽  
The Other ◽  
Lung Damage ◽  
Blocking Agents ◽  
Notable Effect ◽  
Gauge Pressure ◽  
Pulmonary Pathology ◽  
Sympathetic Nervous ◽  
Ganglionic Blocking ◽  
Sympatholytic Agents

The effects of sympathetic blocking agents were studied on rats exposed to O2 at 80 lb. gauge pressure. The ganglionic blocking agents TEAC and hexamethonium reduced the usual convulsive response, lung damage and mortality to a significant degree. On the other hand, the peripheral sympatholytic agents dibenamine, Dibenzyline, and SKF 501 (N-(9-fluorenyl)-N-ethyl-ß-chlorethylamine) lacked a notable effect on the somatic seizure but definitely reduced the pulmonary pathology and mortality. The drug SKF 501 was also found to protect animals exposed to O2 at 80 lb. 80 mm Hg pCO2. But this protection was seen only in the lungs, mortality was about the same as the normals simultaneously exposed. These experiments suggest that hyperactivity of the sympathetic nervous system is the factor primarily responsible for the pulmonary edema and congestion resultant from OHP. It is further indicated that this system also contributes significantly to the hyperoxic seizure and the incidence of mortality.

scholarly journals Double-blind trial of four hypotensive drugs (methyldopa and three sympatholytic agents).

BMJ ◽  
1967 ◽  
Vol 2 (5552) ◽  
pp. 598-600 ◽  
Author(s):  
V. Vejlsgaard ◽  
M. Christensen ◽  
E. Clausen
Keyword(s):  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Hypotensive Drugs ◽  
Sympatholytic Agents

Direct Vasodilators and Sympatholytic Agents

2015 ◽  
Vol 21 (1) ◽  
pp. 3-19 ◽  
Author(s):  
Meghan N. McComb ◽  
James Y. Chao ◽  
Tien M. H. Ng
Keyword(s):  
Sympatholytic Agents

scholarly journals Sympatholytic Agents

Pain Medicine ◽  
2017 ◽  
pp. 193-195
Author(s):  
Yury Khelemsky ◽  
Karina Gritsenko ◽  
Christopher Curatolo
Keyword(s):  
Sympatholytic Agents
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