Effect of Sympathetic Blocking Agents on the Toxic Action of O2 at High Pressure

1957 ◽  
Vol 188 (3) ◽  
pp. 593-598 ◽  
Author(s):  
Paul C. Johnson ◽  
John W. Bean
Keyword(s):  
Significant Degree ◽  
The Other ◽  
Lung Damage ◽  
Blocking Agents ◽  
Notable Effect ◽  
Gauge Pressure ◽  
Pulmonary Pathology ◽  
Sympathetic Nervous ◽  
Ganglionic Blocking ◽  
Sympatholytic Agents

The effects of sympathetic blocking agents were studied on rats exposed to O2 at 80 lb. gauge pressure. The ganglionic blocking agents TEAC and hexamethonium reduced the usual convulsive response, lung damage and mortality to a significant degree. On the other hand, the peripheral sympatholytic agents dibenamine, Dibenzyline, and SKF 501 (N-(9-fluorenyl)-N-ethyl-ß-chlorethylamine) lacked a notable effect on the somatic seizure but definitely reduced the pulmonary pathology and mortality. The drug SKF 501 was also found to protect animals exposed to O2 at 80 lb. 80 mm Hg pCO2. But this protection was seen only in the lungs, mortality was about the same as the normals simultaneously exposed. These experiments suggest that hyperactivity of the sympathetic nervous system is the factor primarily responsible for the pulmonary edema and congestion resultant from OHP. It is further indicated that this system also contributes significantly to the hyperoxic seizure and the incidence of mortality.

Role of Autonomic Nervous System in Maintenance of Cerebral and Renal Hypertension

1957 ◽  
Vol 188 (2) ◽  
pp. 371-374 ◽  
Author(s):  
Sol Rothman ◽  
Douglas R. Drury
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Renal Hypertension ◽  
The Other ◽  
Peripheral Vasculature ◽  
Blood Pressures ◽  
Sympathetic Nervous ◽  
Blood Pressure Responses

The blood pressure responses to various drugs were investigated in renal hypertensive, cerebral hypertensive and normotensive rabbits. Hexamethonium bromide and Dibenamine reduced the blood pressures of renal and cerebral hypertensives. Effects in the normal were insignificant. The cerebral hypertensive's blood pressure was slightly affected by benzodioxane. Blood pressure was not reduced at all in the other groups. Blood pressure of the renal hypertensive rabbit was greatly reduced by Veriloid and dihydroergocornine. Blood pressures of cerebral and normal animals were affected to a lesser degree. The results suggest that maintenance of hypertension in the cerebral hypertensive rabbit depends on an overactive sympathetic nervous system, possibly due to the release of medullary pressor centers from inhibitory impulses originating in higher centers; whereas, the maintenance of hypertension in the renal hypertensive rabbit may be attributed to an increased reactivity of the peripheral vasculature to a normal sympathetic tone.

Albert Schweitzer and the Jews

2014 ◽  
Vol 107 (3) ◽  
pp. 363-398
Author(s):  
James Carleton Paget
Keyword(s):  
Jewish Community ◽  
Academic Career ◽  
Significant Degree ◽  
The Other ◽  
Personal Contact ◽  
Christian Communities ◽  
History Of ◽  
The Subject ◽  
Long Life ◽  
The One

Albert Schweitzer's engagement with Judaism, and with the Jewish community more generally, has never been the subject of substantive discussion. On the one hand this is not surprising—Schweitzer wrote little about Judaism or the Jews during his long life, or at least very little that was devoted principally to those subjects. On the other hand, the lack of a study might be thought odd—Schweitzer's work as a New Testament scholar in particular is taken up to a significant degree with presenting a picture of Jesus, of the earliest Christian communities, and of Paul, and his scholarship emphasizes the need to see these topics against the background of a specific set of Jewish assumptions. It is also noteworthy because Schweitzer married a baptized Jew, whose father's academic career had been disadvantaged because he was a Jew. Moreover, Schweitzer lived at a catastrophic time in the history of the Jews, a time that directly affected his wife's family and others known to him. The extent to which this personal contact with Jews and with Judaism influenced Schweitzer either in his writings on Judaism or in his life will in part be the subject of this article.

scholarly journals A systematic comparison and reliability analysis of formal measures of sentence acceptability

2019 ◽  
Author(s):  
Steven Langsford ◽  
Andrew T Hendrickson ◽  
Amy Perfors ◽  
Lauren Kennedy ◽  
Danielle Navarro
Keyword(s):  
High Reliability ◽  
Significant Degree ◽  
Response Styles ◽  
The Other ◽  
Likert Scales ◽  
Wide Range ◽  
Acceptability Judgments ◽  
Test Retest Reliability ◽  
Item Effects ◽  
Do So

Understanding and measuring sentence acceptability is of fundamental importance for linguists, but although many measures for doing so have been developed, relatively little is known about some of their psychometric properties. In this paper we evaluate within- and between-participant test-retest reliability on a wide range of measures of sentence acceptability. Doing so allows us to estimate how much of the variability within each measure is due to factors including participant-level individual differences, sample size, response styles, and item effects. The measures examined include Likert scales, two versions of forced-choice judgments, magnitude estimation, and a novel measure based on Thurstonian approaches in psychophysics. We reproduce previous findings of high between-participant reliability within and across measures, and extend these results to a generally high reliability within individual items and individual people. Our results indicate that Likert scales and the Thurstonian approach produce the most stable and reliable acceptability measures and do so with smaller sample sizes than the other measures. Moreover, their agreement with each other suggests that the limitation of a discrete Likert scale does not impose a significant degree of structure on the resulting acceptability judgments.

Sympathetic regulation of cerebral blood flow during seizures in newborn lambs

1988 ◽  
Vol 255 (3) ◽  
pp. H563-H568
Author(s):  
C. D. Kurth ◽  
L. C. Wagerle ◽  
M. Delivoria-Papadopoulos
Keyword(s):  
Blood Flow ◽  
Nervous System ◽  
Cerebral Blood Flow ◽  
Sympathetic Nervous System ◽  
Sympathetic Nerves ◽  
The Other ◽  
Cerebral White Matter ◽  
Blood Flows ◽  
Sympathetic Regulation ◽  
Sympathetic Nervous

We examined cerebral blood flow (CBF) regulation by the sympathetic nerves in 12 newborn lambs (3–11 days old) during seizures, a potent reflex stimulator of the sympathetic nervous system. CBF was measured with microspheres, and seizures were induced with bicuculline. In six of these lambs, one hemibrain was denervated (D) chronically by interrupting the ipsilateral cervical sympathetic trunk; the other hemibrain remained innervated (I). Before and after 10, 35, and 70 min of seizures, cerebral gray matter blood flow (mean +/- SE ml.min-1.100 g-1) was, respectively, 12 +/- 3 (9%), 71 +/- 12 (21%), 120 +/- 15 (38%), and 54 +/- 5 (14%) greater (P less than 0.05) in the D than in the I hemibrain. In the cerebral white matter, hippocampus, caudate, and thalamus blood flows to the D and I hemibrains were similar before seizures but during seizures they were 10–39% greater (P less than 0.05) in the D than in the I hemibrain. Midbrain, brainstem, and cerebellum D and I blood flows were always similar. In the other six lambs, acute denervation during seizures increased ipsilateral cerebral gray and hippocampus blood flow by 10–31%, but unilateral electrical stimulation decreased ipsilateral cerebral gray, cerebral white, hippocampus, thalamus, and caudate blood flow by 17–27%. The data demonstrate that, during seizures, sympathetic nerve activity modifies regional CBF and the effect is sustained, suggesting a role for the sympathetic nervous system in newborn CBF regulation.

New Insights on the Mechanisms of Action of Ganglionic Blocking Agents

Physiology ◽  
1990 ◽  
Vol 5 (4) ◽  
pp. 168-172
Author(s):  
VI Skok
Keyword(s):  
Molecular Mechanisms ◽  
Receptor Activation ◽  
Mechanisms Of Action ◽  
Receptor Activity ◽  
Receptor Blockade ◽  
Transmembrane Current ◽  
Blocking Agents ◽  
Ganglionic Blocking

With the use of direct estimations of receptor activity and measurements of agonist-induced transmembrane current, new molecular mechanisms underlying both receptor activation with agonists and receptor blockade with antagonists have been found.

Influence of Ganglionic Blocking Agents on Survival Time in Irradiated Mice

1954 ◽  
Vol 1 (2) ◽  
pp. 176
Author(s):  
Thomas J. Haley ◽  
John Heglin ◽  
Eve McCulloh
Keyword(s):  
Survival Time ◽  
Blocking Agents ◽  
Ganglionic Blocking
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