Notice of Retraction. Shimizu et al. Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients. JAMA Cardiol. 2019;4(3):246-254.

Summary Implantable cardioverters-defibrillators have decreasedmorbidity and mortality as well as improved quality of life in patients with life-threatening cardiac arrhythmias and allowed an increasing number of young women to reach their reproductive years. New questions and tasks arise for medical professionals as to organize appropriate management of these patients, because little is known regarding the risk and outcomes of such pregnancies. The aim of this report is to describe our centre’s first experience of pregnancy and delivery management in patient with an implantable cardioverter-defibrillator as primary prevention of ventricular arrhythmias in congenital long QT syndrome.

Download Full-text

Management of Long QT Syndrome in Women Before, During, and After Pregnancy

US Cardiology Review ◽

10.15420/usc.2021.02 ◽

2021 ◽

Vol 15 ◽

Author(s):

Caroline Taylor ◽

Bruce S Stambler

Keyword(s):

Long Qt Syndrome ◽

Postpartum Period ◽

Torsades De Pointes ◽

Close Monitoring ◽

Cardiac Events ◽

Long Qt ◽

Life Threatening ◽

Β Blocker ◽

Qt Syndrome ◽

Congenital Long Qt Syndrome

Congenital long QT syndrome (LQTS) is a primary genetic and electrical disorder that increases risk for torsades de pointes, syncope, and sudden death. Post-pubertal women with LQTS require specialized multidisciplinary management before, during, and after pregnancy involving cardiology and obstetrics to reduce risk for cardiac events in themselves and their fetuses and babies. The risk of potentially life-threatening events is lower during pregnancy but increases significantly during the 9-month postpartum period. Treatment of women with LQTS with a preferred β-blocker at optimal doses along with close monitoring are indicated throughout pregnancy and during the high-risk postpartum period.

Download Full-text

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Heart Rhythm ◽

10.1016/j.hrthm.2011.03.009 ◽

2011 ◽

Vol 8 (8) ◽

pp. 1207-1213 ◽

Cited By ~ 13

Author(s):

Alon Barsheshet ◽

Derick R. Peterson ◽

Arthur J. Moss ◽

Peter J. Schwartz ◽

Elizabeth S. Kaufman ◽

...

Keyword(s):

Heart Rate ◽

Long Qt Syndrome ◽

Cardiac Events ◽

Long Qt ◽

Life Threatening ◽

Qt Syndrome ◽

Congenital Long Qt Syndrome

Download Full-text

Report of a life-threatening arrhythmia after hospital discharge in a liver transplant recipient with previously unknown congenital long QT syndrome

Digestive and Liver Disease ◽

10.1016/s1590-8658(01)80016-5 ◽

2001 ◽

Vol 33 (5) ◽

pp. 432-434 ◽

Cited By ~ 2

Author(s):

G. Biancofiore ◽

C. Valentini ◽

F. Cellai ◽

F. Filipponi ◽

F. Mosca ◽

...

Keyword(s):

Transplant Recipient ◽

Liver Transplant ◽

Hospital Discharge ◽

Long Qt Syndrome ◽

Liver Transplant Recipient ◽

Long Qt ◽

Life Threatening ◽

Qt Syndrome ◽

Congenital Long Qt Syndrome

Download Full-text

Left thorascopic sympathectomy for refractory long QT syndrome in children

Journal of Neurosurgery Pediatrics ◽

10.3171/2011.8.peds11164 ◽

2011 ◽

Vol 8 (5) ◽

pp. 455-459 ◽

Cited By ~ 5

Author(s):

Steven W. Hwang ◽

Jonathan G. Thomas ◽

William E. Whitehead ◽

Daniel J. Curry ◽

Robert C. Dauser ◽

...

Keyword(s):

Long Qt Syndrome ◽

Pediatric Patients ◽

Relevant Literature ◽

Long Qt ◽

Thoracic Sympathectomy ◽

Life Threatening ◽

Qt Syndrome ◽

Congenital Long Qt Syndrome

Congenital long QT syndrome (LQTS) is a rare genetic ion transmembrane disorder that has been associated with multiple various genetic mutations including life-threatening cardiac arrhythmias and sudden death. Left thorascopic sympathectomy is an effective treatment for patients who are refractory to medical therapy or who need frequent epicardial internal cardiodefibrillator intervention. Although there is substantial literature about this therapy in adults, few reports detail the outcomes in children who undergo left thorascopic sympathectomies to treat LQTS. The authors report the successful use of a left thoracic sympathectomy for the treatment of an 11-year-old girl who had persistently symptomatic LQTS, even after implantation of an automatic cardioverter-defibrillator. The patient remained clinically stable without arrhythmias through 6 months' of follow-up. The authors also reviewed the relevant literature and found that it suggests that 77% of patients will have immediate resolution of their symptoms/arrhythmias after the procedure. When the outcome definition was broadened to include patients who had only 1 or 2 cardiac episodes in the follow-up period, 88% of cases were considered successful. The results of this case study and literature review suggest that left thorascopic sympathectomy is a safe and effective approach for treating pediatric patients with LQTS.

Download Full-text