scholarly journals Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer

2017 ◽  
Author(s):  
Stuart Rundle ◽  
Kristoffer Halvorsrud ◽  
Nicolo Bizzarri ◽  
Nithya DG Ratnavelu ◽  
Ann D Fisher ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Early Stage ◽  
Lymph Node Involvement ◽  
Node Biopsy ◽  
Early Stage Cervical Cancer ◽  
Node Involvement ◽  
Pelvic Lymph Node Involvement

Frozen section examination of sentinel lymph nodes can be used as a decisional tool in the surgical management of early cervical cancer

2020 ◽  
Vol 30 (3) ◽  
pp. 358-363 ◽  
Author(s):  
Agnieszka Rychlik ◽  
Martina Aida Angeles ◽  
Federico Migliorelli ◽  
Sabrina Croce ◽  
Eliane Mery ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Early Stage ◽  
Frozen Section ◽  
Lymph Node Involvement ◽  
Stage Iiic ◽  
Frozen Section Examination ◽  
Early Stage Cervical Cancer ◽  
Node Involvement ◽  
The Impact

IntroductionSentinel lymph node (SLN) detection has been shown to be accurate in detecting lymph node involvement in early-stage cervical cancer. The objective of this study was to evaluate the accuracy of frozen section examination in the assessment of SLN status, with the aim of adequately driving the intra-operative decision.MethodsWe designed a retrospective study including patients from two comprehensive cancer centers between January 2001 and December 2018 with early-stage cervical cancer (IA1-IB2 according to International Federation of Gynecology and Obstetrics (FIGO) 2018) undergoing SLN dissection. The SLN procedure was performed using a cervical injection with technetium-99m combined with blue dye or indocyanine green in most cases.ResultsA total of 176 patients fulfilled inclusion criteria. Bilateral mapping was detected in 153 (86.7%) of them. Nineteen of these patients (12.4%) had SLN involvement: 13 with macrometastases, three with micrometastases and three with isolated tumor cells (ITC). Macrometastatic disease was missed on frozen section in 3/13 FIGO 2018 stage IIIC patients. The three patients with ITC were also missed by frozen section examination.Considering only macrometastases as lymph node involvement, frozen section sensitivity was 76.9% (95% CI 49.7 to 91.8) and negative predictive value (NPV) was 97.9% (95% CI 94.0 to 99.3) in patients with bilateral detection. Including micrometastases, sensitivity was 81.2% (95% CI 57.0 to 93.4) and NPV remained at 97.9% (95% CI 93.9 to 99.3).ConclusionsWith a prevalence of final-stage IIIC in patients with pre-operative early-stage cervical cancer of the order of 10% in this series, the NPV of frozen section examination of SLN is very high, with an inferior limit of the CI superior to 94%. Diagnostic accuracy remains acceptable even if micrometastases are considered. The impact of missed ITC has not been established. Frozen section examination can be incorporated in the intra-operative decision algorithm.

The Microanatomic Location of Metastatic Melanoma in Sentinel Lymph Nodes Predicts Nonsentinel Lymph Node Involvement

2004 ◽  
Vol 22 (16) ◽  
pp. 3345-3349 ◽  
Author(s):  
D.J. Dewar ◽  
B. Newell ◽  
M.A. Green ◽  
A.P. Topping ◽  
B.W.E.M. Powell ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Node ◽  
Metastatic Melanoma ◽  
Sentinel Node Biopsy ◽  
Lymph Node Involvement ◽  
Positive Sentinel Node ◽  
Sentinel Nodes ◽  
Node Biopsy ◽  
Node Involvement ◽  
Nonsentinel Lymph Node

Purpose Sentinel node biopsy is now widely accepted as the most accurate prognostic indicator in melanoma, and is important in guiding management of patients with clinical stage I or II disease. Patients with a positive sentinel node have conventionally undergone completion lymphadenectomy (CLND) of the involved basin, but only 20% have involvement beyond the sentinel node, suggesting that CLND may be unnecessary for the other 80% of patients. This study seeks to identify criteria that might be used to be more restrictive in selecting those who should undergo CLND. Methods A total of 146 patients were identified who had had a positive sentinel node biopsy for malignant melanoma. Their sentinel nodes and lymphadenectomy specimens were re-evaluated pathologically. The metastatic melanoma in each sentinel node was assessed according to its microanatomic location within the node (subcapsular, combined subcapsular and parenchymal, parenchymal, multifocal, or extensive), and this was correlated with the presence of involved nonsentinel nodes in the CLND. The depth of the metastases from the sentinel node capsule was also recorded. Results The metastatic deposits in the sentinel node were subcapsular in 26.0% of patients. None of these patients had any nonsentinel nodes involved on CLND. In the patients whose sentinel node metastases had a different microanatomic location, the rate of nonsentinel node involvement was 22.2% overall. Conclusion The microanatomic location of metastases within sentinel nodes predicts nonsentinel lymph node involvement. In patients with only subcapsular deposits in the sentinel node, it is possible that CLND could safely be avoided.

scholarly journals Sentinel Node Biopsy as an Indicator for Pelvic Nodes Dissection in Early Stage Cervical Cancer

2002 ◽  
Vol 17 (4) ◽  
pp. 507 ◽  
Author(s):  
Chae Chun Rhim ◽  
Jong Sup Park ◽  
Seog Nyeon Bae ◽  
Sung Eun Namkoong
Keyword(s):  
Cervical Cancer ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Early Stage ◽  
Node Biopsy ◽  
Early Stage Cervical Cancer

Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer

2021 ◽  
Vol 2021 (6) ◽  
Author(s):  
Hans Nagar ◽  
Nina Wietek ◽  
Richard J Goodall ◽  
Will Hughes ◽  
Mia Schmidt-Hansen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Lymph Node Involvement ◽  
Node Biopsy ◽  
Node Involvement

305 Level III lymph node involvement cannot be predicted following positive sentinel node biopsy

2010 ◽  
Vol 8 (3) ◽  
pp. 147
Author(s):  
E.K. Romano ◽  
C.C. Kirwan ◽  
M.S. Absar ◽  
S. Pritchard ◽  
M. Wilson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Lymph Node Involvement ◽  
Positive Sentinel Node ◽  
Node Biopsy ◽  
Node Involvement

scholarly journals Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5423
Author(s):  
Vincent Balaya ◽  
Benedetta Guani ◽  
Julie Mereaux ◽  
Laurent Magaud ◽  
Basile Pache ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Stage ◽  
Figo Stage ◽  
Lymph Node Involvement ◽  
Lymph Node Status ◽  
Pathologic Features ◽  
Early Stage Cervical Cancer ◽  
Node Involvement

Background: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric database on SLN biopsy for cervical cancer (SENTICOL I and II) was carried out. Patients with IA to IB2 2018 FIGO stage, who underwent preoperative conization before SLN biopsy were included. Results: Between January 2005 and July 2012, 161 patients from 25 French centers fulfilled the inclusion criteria. Macrometastases, micrometastases and Isolated tumor cells (ITCs) were found in 4 (2.5%), 6 (3.7%) and 5 (3.1%) patients respectively. Compared to negative SLN patients, patients with micrometastatic and macrometastatic SLN were more likely to have lymphovascular space invasion (LVSI) (60% vs. 29.5%, p = 0.04) and deep stromal invasion (DSI) ≥ 10 mm (50% vs. 17.8%, p = 0.04). Among the 93 patients with DSI < 10 mm and absence of LVSI on conization specimens, three patients (3.2%) had ITCs and only one (1.1%) had micrometastases. Conclusions: Patients with DSI < 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN. In this subpopulation, full node dissection may be questionable in case of SLN unilateral detection.

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