scholarly journals Structure of OxyAtei: completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade

FEBS Letters ◽  
2016 ◽  
Vol 590 (4) ◽  
pp. 571-581 ◽  
Author(s):  
Kristina Haslinger ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Glycopeptide Antibiotic

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

2016 ◽  
Vol 12 (10) ◽  
pp. 2992-3004 ◽  
Author(s):  
Veronika Ulrich ◽  
Madeleine Peschke ◽  
Clara Brieke ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Coupling Reaction ◽  
Glycopeptide Antibiotic

Cytochrome P450 StaH catalyses the first cyclisation reaction in the biosynthesis of the glycopeptide antibiotic A47934 via recruitment to the NRPS machinery through interaction with the X-domain.

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

2015 ◽  
Vol 13 (7) ◽  
pp. 2012-2021 ◽  
Author(s):  
Clara Brieke ◽  
Veronika Kratzig ◽  
Kristina Haslinger ◽  
Andreas Winkler ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Biomimetic Synthesis ◽  
Carrier Protein ◽  
Cytochrome P450 Enzyme ◽  
Glycopeptide Antibiotics ◽  
Glycopeptide Antibiotic ◽  
Rapid Access ◽  
P450 Enzyme ◽  
Mediated Catalysis

One Cytochrome P450 enzyme performs the phenolic crosslinking of a range of chemically synthesized, carrier-protein loaded glycopeptide antibiotic precursor peptides.

Chlorinated Glycopeptide Antibiotic Peptide Precursors Improve Cytochrome P450-Catalyzed Cyclization Cascade Efficiency

Biochemistry ◽  
2017 ◽  
Vol 56 (9) ◽  
pp. 1239-1247 ◽  
Author(s):  
Madeleine Peschke ◽  
Clara Brieke ◽  
Rob J. A. Goode ◽  
Ralf B. Schittenhelm ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Glycopeptide Antibiotic ◽  
Peptide Precursors ◽  
Antibiotic Peptide

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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