More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

2016 ◽  
Vol 12 (10) ◽  
pp. 2992-3004 ◽  
Author(s):  
Veronika Ulrich ◽  
Madeleine Peschke ◽  
Clara Brieke ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Coupling Reaction ◽  
Glycopeptide Antibiotic

Cytochrome P450 StaH catalyses the first cyclisation reaction in the biosynthesis of the glycopeptide antibiotic A47934 via recruitment to the NRPS machinery through interaction with the X-domain.

scholarly journals Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis

2002 ◽  
Vol 277 (49) ◽  
pp. 47476-47485 ◽  
Author(s):  
Katja Zerbe ◽  
Olena Pylypenko ◽  
Francesca Vitali ◽  
Weiwen Zhang ◽  
Severine Rouset ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Coupling Reaction

An Oxidative Phenol Coupling Reaction Catalyzed by OxyB, a Cytochrome P450 from the Vancomycin-Producing Microorganism

2004 ◽  
Vol 43 (48) ◽  
pp. 6709-6713 ◽  
Author(s):  
Katja Zerbe ◽  
Katharina Woithe ◽  
Dong Bo Li ◽  
Francesca Vitali ◽  
Laurent Bigler ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Coupling Reaction

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

2015 ◽  
Vol 13 (7) ◽  
pp. 2012-2021 ◽  
Author(s):  
Clara Brieke ◽  
Veronika Kratzig ◽  
Kristina Haslinger ◽  
Andreas Winkler ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Biomimetic Synthesis ◽  
Carrier Protein ◽  
Cytochrome P450 Enzyme ◽  
Glycopeptide Antibiotics ◽  
Glycopeptide Antibiotic ◽  
Rapid Access ◽  
P450 Enzyme ◽  
Mediated Catalysis

One Cytochrome P450 enzyme performs the phenolic crosslinking of a range of chemically synthesized, carrier-protein loaded glycopeptide antibiotic precursor peptides.

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