scholarly journals RNA polymerase pausing at a protein roadblock can enhance transcriptional interference by promoter occlusion

FEBS Letters ◽  
2019 ◽  
Vol 593 (9) ◽  
pp. 903-917 ◽  
Author(s):  
Nan Hao ◽  
Michael T. Crooks ◽  
Adam C. Palmer ◽  
Ian B. Dodd ◽  
Keith E. Shearwin
Keyword(s):  
Rna Polymerase ◽  
Transcriptional Interference ◽  
Polymerase Pausing

scholarly journals Splicing-Dependent RNA Polymerase Pausing in Yeast

2010 ◽  
Vol 40 (4) ◽  
pp. 582-593 ◽  
Author(s):  
Ross D. Alexander ◽  
Steven A. Innocente ◽  
J. David Barrass ◽  
Jean D. Beggs
Keyword(s):  
Rna Polymerase ◽  
Polymerase Pausing

scholarly journals Pause & go: from the discovery of RNA polymerase pausing to its functional implications

2017 ◽  
Vol 46 ◽  
pp. 72-80 ◽  
Author(s):  
Andreas Mayer ◽  
Heather M Landry ◽  
L Stirling Churchman
Keyword(s):  
Rna Polymerase ◽  
Functional Implications ◽  
Polymerase Pausing

scholarly journals BORDER proteins protect expression of neighboring genes by promoting 3′ Pol II pausing in plants

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Xuhong Yu ◽  
Pascal G. P. Martin ◽  
Scott D. Michaels
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Promoter Region ◽  
Transcriptional Interference ◽  
Genomic Context ◽  
Upstream Gene ◽  
Insulator Proteins ◽  
Intergenic Regions ◽  
Pol Ii Pausing ◽  
And Shifts

Abstract Ensuring that one gene’s transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms that prevent transcriptional interference are not well understood. Here we show that BORDER proteins are enriched in intergenic regions and prevent interference between closely spaced genes on the same strand by promoting the 3′ pausing of RNA polymerase II at the upstream gene. In the absence of BORDER proteins, 3′ pausing associated with the upstream gene is reduced and shifts into the promoter region of the downstream gene. This is consistent with a model in which BORDER proteins inhibit transcriptional interference by preventing RNA polymerase from intruding into the promoters of downstream genes.

scholarly journals Possible roles of σ-dependent RNA polymerase pausing in transcription regulation

RNA Biology ◽  
2017 ◽  
Vol 14 (12) ◽  
pp. 1678-1682 ◽  
Author(s):  
Ivan Petushkov ◽  
Daria Esyunina ◽  
Andrey Kulbachinskiy
Keyword(s):  
Rna Polymerase ◽  
Transcription Regulation ◽  
Polymerase Pausing
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