Time‐Lapse Imaging of Embryonic Neural Stem Cell Division in Drosophila by Two‐Photon Microscopy

2010 ◽  
Vol 13 (1) ◽  
Author(s):  
Elena Rebollo ◽  
Cayetano Gonzalez
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Time Lapse ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Stem Cell Division ◽  
Embryonic Neural Stem Cell ◽  
Time Lapse Imaging

scholarly journals Novel insights into mammalian embryonic neural stem cell division: focus on microtubules

2015 ◽  
Vol 26 (24) ◽  
pp. 4302-4306 ◽  
Author(s):  
Felipe Mora-Bermúdez ◽  
Wieland B. Huttner
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Spindle Orientation ◽  
Stem Cell Divisions ◽  
A Cell ◽  
Spindle Microtubules ◽  
Stem Cell Division ◽  
Embryonic Neural Stem Cell

During stem cell divisions, mitotic microtubules do more than just segregate the chromosomes. They also determine whether a cell divides virtually symmetrically or asymmetrically by establishing spindle orientation and the plane of cell division. This can be decisive for the fate of the stem cell progeny. Spindle defects have been linked to neurodevelopmental disorders, yet the role of spindle orientation for mammalian neurogenesis has remained controversial. Here we explore recent advances in understanding how the microtubule cytoskeleton influences mammalian neural stem cell division. Our focus is primarily on the role of spindle microtubules in the development of the cerebral cortex. We also highlight unique characteristics in the architecture and dynamics of cortical stem cells that are tightly linked to their mode of division. These features contribute to setting these cells apart as mitotic “rule breakers,” control how asymmetric a division is, and, we argue, are sufficient to determine the fate of the neural stem cell progeny in mammals.

scholarly journals Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division

2018 ◽  
Vol 32 (23-24) ◽  
pp. 1550-1561 ◽  
Author(s):  
Hideyuki Komori ◽  
Krista L. Golden ◽  
Taeko Kobayashi ◽  
Ryoichiro Kageyama ◽  
Cheng-Yu Lee
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Gene Control ◽  
Cell State ◽  
Stem Cell Division ◽  
Stem Cell State

scholarly journals Continuous live imaging of adult neural stem cell division and lineage progression in vitro

Development ◽  
2011 ◽  
Vol 138 (6) ◽  
pp. 1057-1068 ◽  
Author(s):  
M. R. Costa ◽  
F. Ortega ◽  
M. S. Brill ◽  
R. Beckervordersandforth ◽  
C. Petrone ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Live Imaging ◽  
Adult Neural Stem Cell ◽  
Stem Cell Division

scholarly journals Characterizing the role of Eg5 kinesin on mediating neural stem cell division in the developing zebrafish neural tube

2011 ◽  
Vol 356 (1) ◽  
pp. 215-216
Author(s):  
Kimberly A. Johnson ◽  
Chelsea Moriarty ◽  
Alissa Ortman ◽  
Rebecca Bernardos ◽  
Kim Chi Ngo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Neural Tube ◽  
Stem Cell Division

scholarly journals Image analysis of neural stem cell division patterns in the zebrafish brain

2017 ◽  
Vol 93 (3) ◽  
pp. 314-322 ◽  
Author(s):  
Valerio Lupperger ◽  
Felix Buggenthin ◽  
Prisca Chapouton ◽  
Carsten Marr
Keyword(s):  
Image Analysis ◽  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Zebrafish Brain ◽  
Stem Cell Division

scholarly journals Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

Cell Reports ◽  
2018 ◽  
Vol 25 (12) ◽  
pp. 3231-3240.e8 ◽  
Author(s):  
Lisa Bast ◽  
Filippo Calzolari ◽  
Michael K. Strasser ◽  
Jan Hasenauer ◽  
Fabian J. Theis ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Age Related ◽  
Stem Cell Division
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