In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations

2007 ◽  
pp. 853-877
Author(s):  
Albert P. Li
Keyword(s):  
Drug Interactions ◽  
Scientific Concepts ◽  
Metabolic Drug ◽  
In Vitro Evaluation

A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo

2020 ◽  
Vol 12 (16) ◽  
pp. 2166-2175 ◽  
Author(s):  
Dong-Gyun Han ◽  
Kyu-Sang Kim ◽  
Seong-Wook Seo ◽  
Young Mee Baek ◽  
Yunjin Jung ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Drug Interactions ◽  
Simultaneous Determination ◽  
Small Volume ◽  
Rat Plasma ◽  
Metabolic Drug ◽  
Simple Sample Preparation

We developed a sensitive, simple and validated HPLC-FL method for simultaneous determination of FEB and DIC in rat plasma. The method requires a relatively small volume of sample, has simple sample preparation and excellent sensitivity.

In vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor

Xenobiotica ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. 314-323
Author(s):  
Yukihiro Chino ◽  
Masatoshi Hasegawa ◽  
Yoshiki Fukasawa ◽  
Yoko Mano ◽  
Kagumi Bando ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Sglt2 Inhibitor ◽  
Potential Drug ◽  
In Vitro Evaluation
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