Development of Enteric Neurons from Non-Recognizable Precursor Cells

2008 ◽  
pp. 51-69
Author(s):  
Michael D. Gershon ◽  
Gladys Teitelman ◽  
Taube P. Rothman
Keyword(s):  
Precursor Cells ◽  
Enteric Neurons

Developmental regulation of GDNF response and receptor expression in the enteric nervous system

Development ◽  
2000 ◽  
Vol 127 (20) ◽  
pp. 4383-4393
Author(s):  
D.S. Worley ◽  
J.M. Pisano ◽  
E.D. Choi ◽  
L. Walus ◽  
C.A. Hession ◽  
...  
Keyword(s):  
Nervous System ◽  
Cell Surface ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Developmental Stages ◽  
Developmental Regulation ◽  
Precursor Cells ◽  
Receptor Expression ◽  
Enteric Neurons ◽  
Maximal Response

The development of the enteric nervous system is dependent upon the actions of glial cell line-derived neurotrophic factor (GDNF) on neural crest-derived precursor cells in the embryonic gut. GDNF treatment of cultured enteric precursor cells leads to an increase in the number of neurons that develop and/or survive. Here we demonstrate that, although GDNF promoted an increase in neuron number at all embryonic ages examined, there was a developmental shift from a mitogenic to a trophic response by the developing enteric neurons. The timing of this shift corresponded to developmental changes in gut expression of GFR alpha-1, a co-receptor in the GDNF-Ret signaling complex. GFR alpha-1 was broadly expressed in the gut at early developmental stages, at which times soluble GFR alpha-1 was released into the medium by cultured gut cells. At later times, GFR alpha-1 became restricted to neural crest-derived cells. GFR alpha-1 could participate in GDNF signaling when expressed in cis on the surface of enteric precursor cells, or as a soluble protein. The GDNF-mediated response was greater when cell surface, compared with soluble, GFR alpha-1 was present, with the maximal response seen the presence of both cis and trans forms of GFR alpha-1. In addition to contributing to GDNF signaling, cell-surface GFR alpha-1 modulated the specificity of interactions between GDNF and soluble GFR alphas. These experiments demonstrate that complex, developmentally regulated, signaling interactions contribute to the GDNF-dependent development of enteric neurons.

506: Restoration of Innervated Urinary Sphincter Function Using Muscle Precursor Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 135-135
Author(s):  
Rene Yiou ◽  
James J. Yoo ◽  
Anthony Atala
Keyword(s):  
Precursor Cells ◽  
Sphincter Function ◽  
Muscle Precursor ◽  
Urinary Sphincter ◽  
Muscle Precursor Cells

The influence of T-lymphocyte precursor cells and thymus grafts on the cellular immunodeficiencies of the BB rat

Diabetes ◽  
1985 ◽  
Vol 34 (11) ◽  
pp. 1134-1138 ◽  
Author(s):  
J. W. Francfort ◽  
A. Naji ◽  
W. K. Silvers ◽  
C. F. Barker
Keyword(s):  
T Lymphocyte ◽  
Precursor Cells ◽  
Bb Rat
Sign in / Sign up

Export Citation Format

Share Document