Sequence Covariation Analysis in Biological Polymers

2019 ◽  
pp. 325-30
Author(s):  
William R. Taylor ◽  
Shaun Kandathil ◽  
David T. Jones
2004 ◽  
Vol 40 (1) ◽  
pp. 5-25 ◽  
Author(s):  
David Cunliffe ◽  
Sivanand Pennadam ◽  
Cameron Alexander
Keyword(s):  

2000 ◽  
Vol 33 (2) ◽  
pp. 647-647
Author(s):  
Chritopher Y. Li ◽  
Donghang Yan ◽  
Stephen Z. D. Cheng ◽  
Feng Bai ◽  
Tianbai He ◽  
...  

Author(s):  
John Emsley

You may think of polymers as entirely manufactured and therefore unnatural, but they are often the chemists’ attempts to supplement and improve on the biological polymers that nature produces. Cotton, ivory, leather, linen, paper, rubber, silk, wood and wool are wonderful materials made from the biological polymers that plants and animals produce, and which have evolved to serve such useful ends as providing protective outer layers, insulation, reinforcement, weaponry and so on. Humans learned that with a little modification they could turn these polymers into quite useful articles, such as briefs and briefcases, condoms and tea cosies, tickets and toothpicks. Sometimes we want polymers with features that never evolved in nature, such as non-cracking insulation for electric cable, clothes that can be unpacked after a long voyage and still be without creases, or pans in which to fry eggs without them sticking. For these polymers we have had to look to chemists. Most of the portraits in this Gallery are of these kinds of polymers—materials that do not have natural equivalents. Polymers are rather special kinds of molecules consisting of long chains, usually made up of carbon atoms, to which other atoms, such as hydrogen, fluorine and chlorine, are attached. The older name for polymers is plastics, and you probably know several of them by name— polythene, polystyrene, Teflon, Orion—but these are only a few of the many that now play an important role in our lives. Whatever role polymers play, they cause many of us to adopt quite strong attitudes towards them. A few of us admire them, many of us ignore them, but a growing number despise them and a few abhor them and will avoid them at all costs. To a chemist, this opposition to polymers seems rather strange. By the time you come to the end of this exhibition I hope that visitors with strong views will have seen enough to persuade them to change their mind. Attitudes towards plastics have changed over the past half-century. In the 19305, when cellophane, PVC, polystyrene, Perspex and nylon were launched, plastics were welcomed.


2020 ◽  
Vol 16 ◽  
pp. 2260-2271
Author(s):  
Akul Y Mehta ◽  
Jamie Heimburg-Molinaro ◽  
Richard D Cummings

Glycans are one of the major biological polymers found in the mammalian body. They play a vital role in a number of physiologic and pathologic conditions. Glycan microarrays allow a plethora of information to be obtained on protein–glycan binding interactions. In this review, we describe the intricacies of the generation of glycan microarray data and the experimental methods for studying binding. We highlight the importance of this knowledge before moving on to the data analysis. We then highlight a number of tools for the analysis of glycan microarray data such as data repositories, data visualization and manual analysis tools, automated analysis tools and structural informatics tools.


Author(s):  
Dmitri V. Alexandrov ◽  
Andrey Yu. Zubarev

This issue is concerned with structural and phase transitions in heterogeneous and composite materials, the effects of external magnetic fields on these phenomena and the macroscopic properties and behaviour of materials with isotropic and anisotropic internal structures. Using experimental, theoretical and computer methods, these transitions are studied at the atomic and mesoscopic levels. The fundamental specific feature of structural transitions in many heterogeneous media consists of the fact that these transitions are stacked for a long time in non-equilibrium states that appear due to either macroscopic dissipative processes (an alternating magnetic field or hydrodynamic flow, for instance) or system lifetime in a metastable state. It is important to explain and describe these transitional states using the general approach of non-equilibrium physical mechanics. The review and research articles in the issue will cover the whole spectrum of scales (from nano to macro) and materials (from metastable liquids to biological polymers) in order to exhibit recently developed trends in the field of heterogeneous materials. Atomistic modelling, structuring induced by external magnetic fields and hydrodynamic flows, metastable and non-ergodic states, mechanical properties and phenomena in heterogeneous materials—all these are covered. This article is part of the theme issue ‘Heterogeneous materials: metastable and non-ergodic internal structures’.


2019 ◽  
Vol 10 (36) ◽  
pp. 4930-4934
Author(s):  
Jamie A. Nowalk ◽  
Jordan H. Swisher ◽  
Tara Y. Meyer

Despite the known sensitivity to sequence mutations of biological polymers, little is known about the effects of errors in sequenced synthetic copolymers.


2016 ◽  
Vol 48 (3) ◽  
pp. 249-252
Author(s):  
M. I. Shtil′man ◽  
Ya. O. Mezhuev
Keyword(s):  

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