Microfluidic Approaches and Methods Enabling Extracellular Vesicle Isolation for Cancer Diagnostics

Advances in cancer research over the past half-century have clearly determined the molecular origins of the disease. Central to the use of molecular signatures for continued progress, including rapid, reliable, and early diagnosis is the use of biomarkers. Specifically, extracellular vesicles as biomarker cargo holders have generated significant interest. However, the isolation, purification, and subsequent analysis of these extracellular vesicles remain a challenge. Technological advances driven by microfluidics-enabled devices have made the challenges for isolation of extracellular vesicles an emerging area of research with significant possibilities for use in clinical settings enabling point-of-care diagnostics for cancer. In this article, we present a tutorial review of the existing microfluidic technologies for cancer diagnostics with a focus on extracellular vesicle isolation methods.

The characteristics of early-stage research into human genes are substantially different from subsequent research

Throughout the last 2 decades, several scholars observed that present day research into human genes rarely turns toward genes that had not already been extensively investigated in the past. Guided by hypotheses derived from studies of science and innovation, we present here a literature-wide data-driven meta-analysis to identify the specific scientific and organizational contexts that coincided with early-stage research into human genes throughout the past half century. We demonstrate that early-stage research into human genes differs in team size, citation impact, funding mechanisms, and publication outlet, but that generalized insights derived from studies of science and innovation only partially apply to early-stage research into human genes. Further, we demonstrate that, presently, genome biology accounts for most of the initial early-stage research, while subsequent early-stage research can engage other life sciences fields. We therefore anticipate that the specificity of our findings will enable scientists and policymakers to better promote early-stage research into human genes and increase overall innovation within the life sciences.

Mothers’ Behaviors and Children’s Social Confidence and Ability: Correlations from the NLSY

The understanding of shyness and social withdrawal has been built over the past half century with research looking into factors that cause this in children. However, not many mention the natural phenomenon of if children mimic social confidence from their adult figure. This study used correlation analyses to investigate the relations between parents’ behaviors and attitudes and their children’s social confidence and ability. Data were from the National Longitudinal Survey of Youth, 1986 Child and Young Adult Survey Mother Supplement. Results showed weak correlation between social confidence and outings frequency, either with family and friends or not. However, children who were spanked more frequently positively correlated with their mothers rating them to be more high strung. Furthermore, all hypotheses showed results that follow the direction of the prediction, so further investigation into the topic may show more significant correlation or a causation relationship of the variables.

“Spend your spoons wisely”: Conceptualizations of time, energy and aging invisibly with Crohn’s Disease

An increasing number of people with chronic medical disabilities are living longer and into old age due to the growing medical and technological advancements over the past half century. We used grounded theory to examine the lived experience of aging “with” a disability in a non-elderly population. On average, participants were 37 years of age at the time of interview. The average time since diagnosis was 17 years and ranged from 3 to 34 years. Many worked full-time outside of the home and some held advanced or graduate degrees. Of the 35 participants interviewed, three-quarters expressed worries about the future and aging, specifically related to physical limitations of having CD. The other 25% talked about learning to accept the diagnosis and ‘moving forward’ with their life as they age. All participants described the difficulties of fatigue and energy limitations. Planning of life was limited to 24 hours — a direct consequence of functional limitations of a relapsing-remitting disease. The most prominent theme that emerged from participants’ narratives to explain aging invisibly with a chronic illness was quantifying energy into ‘spoons’, a way of measuring the stock of their energy on any given day. These findings translate into important insights into the process of aging for those who live and age “with” Crohn’s as their everyday lives are immersed in managing the varying whims of this illness.

2020 ASR Distinguished Lecture: African Voices Matter: Reflections on Fifty Years of Historical Research in Southern Africa

The recent racial reckoning has challenged scholars to recover Black voices that have been erased from historical accounts. This essay is my reflections on the challenges I faced in conducting research on African voices in politically and racially charged settings in Lesotho and South Africa over the past half century. After the political atmosphere began changing in South Africa in 1990, I served the individuals and communities I write about by rectifying historical injustices such as returning a holy relic to a religious group, the Israelites, and facilitating the return of remains of Nontetha Nkwenkwe from a pauper’s grave in Pretoria to her home.

Paradoxes and prospects of the glocal

Globalism has demonstrated both its power and helplessness in creating human qualities of the environment. The latter was a matter of architecture, but it has been a victim of a narrowed and reduced model of globalism, a modernist model. Surmounting the crisis that has taken the past half century cannot be considered complete yet. At present, one can see the problems and prospects of new syntheses of the universal and the local, without which it is impossible to imagine the comprehensive future of the planet.

Disability

Disability presents a key challenge for modern welfare states. It has been a core policy concern throughout their evolution, but the concept of disability, and what it means for public policy, has changed radically in the past half-century. Disability is now widely understood, from a social model perspective, as an issue of social inclusion and social justice. It is also framed by increasingly coherent international human rights frameworks. The chapter reviews changing ideas about disability, and changing policy responses to it, from the early origins of the welfare state to the contemporary global governance of human rights. It examines approaches to disability policy in terms of cash and in-kind entitlements, employment-focused policies, and broader rights-based approaches. Disability is a flexible administrative category that has been deployed selectively to control of labour supply and welfare entitlement. Reframing national disability policies within a global discourse of social rights has been an important development, but rights-based legislation alone is unlikely to resolve its structural basis in capitalist markets and there is still little evidence of marked improvement in aggregate social outcomes for disabled people.