scholarly journals External dosimetry audit for quality assurance of carbon-ion radiation therapy clinical trials

2018 ◽  
Vol 20 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Hideyuki Mizuno ◽  
Akifumi Fukumura ◽  
Nobuyuki Kanematsu ◽  
Shunsuke Yonai ◽  
Toshiyuki Shirai ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Quality Assurance ◽  
Radiation Therapy ◽  
Carbon Ion

scholarly journals Clinical trials involving carbon‐ion radiation therapy and the path forward

Cancer ◽  
2018 ◽  
Vol 124 (23) ◽  
pp. 4467-4476 ◽  
Author(s):  
Ann A. Lazar ◽  
Reinhard Schulte ◽  
Bruce Faddegon ◽  
Eleanor A. Blakely ◽  
Mack Roach
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Carbon Ion

scholarly journals Multicentre dose audit for clinical trials of radiation therapy in Asia

2016 ◽  
Vol 58 (3) ◽  
pp. 372-377 ◽  
Author(s):  
Hideyuki Mizuno ◽  
Shigekazu Fukuda ◽  
Akifumi Fukumura ◽  
Yuzuru-Kutsutani Nakamura ◽  
Cao Jianping ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Quality Assurance ◽  
Radiation Therapy ◽  
Radiation Dosimetry ◽  
Quality Assurance Program ◽  
Relative Deviation ◽  
Single Beam ◽  
Tolerance Level ◽  
Audit System

Abstract A dose audit of 16 facilities in 11 countries has been performed within the framework of the Forum for Nuclear Cooperation in Asia (FNCA) quality assurance program. The quality of radiation dosimetry varies because of the large variation in radiation therapy among the participating countries. One of the most important aspects of international multicentre clinical trials is uniformity of absolute dose between centres. The National Institute of Radiological Sciences (NIRS) in Japan has conducted a dose audit of participating countries since 2006 by using radiophotoluminescent glass dosimeters (RGDs). RGDs have been successfully applied to a domestic postal dose audit in Japan. The authors used the same audit system to perform a dose audit of the FNCA countries. The average and standard deviation of the relative deviation between the measured and intended dose among 46 beams was 0.4% and 1.5% (k = 1), respectively. This is an excellent level of uniformity for the multicountry data. However, of the 46 beams measured, a single beam exceeded the permitted tolerance level of ±5%. We investigated the cause for this and solved the problem. This event highlights the importance of external audits in radiation therapy.

Physical and Biological Basis of Proton and of Carbon Ion Radiation Therapy and Clinical Outcome Data

2009 ◽  
Vol 02 (01) ◽  
pp. 1-15 ◽  
Author(s):  
Herman Suit ◽  
Thomas F. Delaney ◽  
Alexei Trofimov
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Dose Distribution ◽  
Particle Beam ◽  
Initial Energy ◽  
Outcome Data ◽  
Ion Beams ◽  
Phase Iii ◽  
Dose Fractionation ◽  
Carbon Ion

There is a clear basis in physics for the clinical use of proton and carbon beams in radiation therapy, namely, the finite range of the particle beam. The range is dependent on the beam initial energy, density and atomic composition of tissues along the beam path. Beams can be designed that penetrate to the required depth and deliver a uniform biologically effective dose across the depth of interest. The yield is a superior dose distribution relative to photon beams. There is a potential clinical advantage from the high linear energy transfer (LET) characteristics of carbon beams. This is based on a lower oxygen enhancement ratio (OER) and a flatter age response function. However, due to uncertainties relating OER with relative biological effectiveness (RBE), there is no clinical evidence to date that carbon ion beams have an advantage over proton beams. We strongly support performance Phase III clinical trials of protons vs carbon ion beams designed to feature a single variable, LET. Dose fractionation would be identical in both arms and dose distribution would be similar for the sites to be tested. For sites for which the carbon beam has a demonstrated important advantage in comparative treatment planning due to the narrower penumbra would not be selected for the clinical trials.

Carbon ion radiation therapy for chordomas and low grade chondrosarcomas - current status of the clinical trials at GSI-

2004 ◽  
Vol 73 ◽  
pp. S53-S56 ◽  
Author(s):  
Daniela Schulz-Ertner ◽  
Anna Nikoghosyan ◽  
Bernd Didinger ◽  
Jürgen Debus
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Current Status ◽  
Low Grade ◽  
Carbon Ion

The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonization Group Recommendations for Сontouring of OARs

2021 ◽  
Vol 91 (3) ◽  
pp. 5-16
Author(s):  
A. V. Bondarenko ◽  
Zh. S. Lebedeva ◽  
A. P. Litvinov
Keyword(s):  
Clinical Trials ◽  
Quality Assurance ◽  
Radiation Therapy ◽  
Organs At Risk ◽  
Healthcare Facility ◽  
Global Quality ◽  
Risk Increase ◽  
Dose Limits ◽  
The Creation ◽  
The Many

QUANTEC report summarized the data of the dose constrains for critical structures in radiotherapy. The authors of this report determined that one of the obstacles to obtaining meaningful data on tolerant doses was inconsistency in the nomenclature of names. And inconsistencies in the guidelines for contouring the organs at risk increase the variability in contouring. Eliminating these inconsistencies increases the speed and safety of the workflow within each individual healthcare facility and improves the accuracy and reliability of the data underlying the dose limits that are developed. The standardization of terminology facilitates the integration of dosimetry data, the creation of various templates and scripts to automate the creation of a prescription for the RT course for similar cases, and the automation of reports. It helps to train the systems supporting artificial intelligence. AAPM report TG-263 resolved the nomenclature problem, however, different anatomical boundaries of different organs were still hidden under the same names in various large research centers. In 2020 The Global Quality Assurance of Radiation Therapy Clinical Trials Harmonization Group published an article. It summarized the many years of work by the scientific radiotherapy community to standardize the approach to delineating the OARs. This article provides an overview of the article key points and provides links to outline guides. A special attention it was paid to clarifying the anatomical boundaries of such OARs: heart, femoral heads, skin, individual structures of the gastrointestinal tract and substructures of the eye.

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