scholarly journals Qntifying the impact of SpaceOAR hydrogel on inter‐fractional rectal and bladder dose during 0.35 T MR‐guided prostate adaptive radiotherapy

2021 ◽  
Author(s):  
Reza Farjam ◽  
Sean S. Mahase ◽  
Shu Ling Chen ◽  
Madeline Coonce ◽  
Ryan T. Pennell ◽  
...  
Keyword(s):  
Adaptive Radiotherapy ◽  
The Impact ◽  
Spaceoar Hydrogel

scholarly journals Adaptive radiotherapy for head and neck cancer

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Enis Tinjak ◽  
Velda Smajlbegović ◽  
Adnan Beganović ◽  
Mirjana Ristanić ◽  
Halil Ćorović ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Adaptive Radiotherapy ◽  
Tumor Control ◽  
Parotid Glands ◽  
Image Guided Radiotherapy ◽  
The Impact

Introduction: Radiation therapy has long played an integral role in the manage¬ment of locally advanced head and neck cancer (HNC), both for organ preservation and to improve tumor control in the postoperative setting. The aim of this research is to investigate the effects of adaptive radiotherapy on dosimetric, clinical, and toxicity outcomes for patients with head and neck cancer undergoing radiation therapy treatment. Many sources have reported volume reductions in the primary target, nodal volumes, and parotid glands over treatment, which may result in unintended dosimetric changes affecting the side effect profile and even efficacy of the treatment. Adaptive radiotherapy (ART) is an interesting treatment paradigm that has been developed to directly adjust to these changes.Material and methods: This research contains the results of 15 studies, including clinical trials, randomized prospective and retrospective studies. The researches analyze the impact of radiation therapy on changes in tumor volume and the relationship with planned radiation dose delivery, as well as the possibility of using adaptive radiotherapy in response to identified changes. Also, medical articles and abstracts that are closely related to the title of adaptive radiotherapy were researched.Results: The application of ART significantly improved the quality of life of patients with head and neck cancer, as well as two-year locoregional control of the disease. The average time to apply ART is the middle of the treatment course approximately 17 to 20 fractions of the treatment.Conclusion: Based on systematic review of the literature, evidence based changes in target volumes and dose reduction at OAR, adaptive radiotherapy is recommended treatment for most of the patients with head and neck cancer with the support of image-guided radiotherapy.

scholarly journals Adaptive radiotherapy for head and neck cancer

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Howard E. Morgan ◽  
David J. Sher
Keyword(s):  
Head And Neck ◽  
Normal Tissue ◽  
Adaptive Radiotherapy ◽  
Response To Treatment ◽  
Main Body ◽  
Parotid Glands ◽  
Spatial Changes ◽  
Treatment Paradigm ◽  
Many Sources ◽  
The Impact

Abstract Background Although there have been dramatic improvements in radiotherapy for head and neck squamous cell carcinoma (HNSCC), including robust intensity modulation and daily image guidance, these advances are not able to account for inherent structural and spatial changes that may occur during treatment. Many sources have reported volume reductions in the primary target, nodal volumes, and parotid glands over treatment, which may result in unintended dosimetric changes affecting the side effect profile and even efficacy of the treatment. Adaptive radiotherapy (ART) is an exciting treatment paradigm that has been developed to directly adjust for these changes. Main body Adaptive radiotherapy may be divided into two categories: anatomy-adapted (A-ART) and response-adapted ART (R-ART). Anatomy-adapted ART is the process of re-planning patients based on structural and spatial changes occurring over treatment, with the intent of reducing overdosage of sensitive structures such as the parotids, improving dose homogeneity, and preserving coverage of the target. In contrast, response-adapted ART is the process of re-planning patients based on response to treatment, such that the target and/or dose changes as a function of interim imaging during treatment, with the intent of dose escalating persistent disease and/or de-escalating surrounding normal tissue. The impact of R-ART on local control and toxicity outcomes is actively being investigated in several currently accruing trials. Conclusions Anatomy-adapted ART is a promising modality to improve rates of xerostomia and coverage in individuals who experience significant volumetric changes during radiation, while R-ART is currently being studied to assess its utility in either dose escalation of radioresistant disease, or de-intensification of surrounding normal tissue following treatment response. In this paper, we will review the existing literature and recent advances regarding A-ART and R-ART.

CBCT-BASED VOLUME DEFINITION: BENCHMARKED INTER-OBSERVER VARIABILITY AND THE IMPACT ON ADAPTIVE RADIOTHERAPY

2009 ◽  
Vol 92 ◽  
pp. S119
Author(s):  
C. Luetgendorf-Caucig ◽  
I. Fotina ◽  
M. Stock ◽  
D. Georg ◽  
R. Pötter ◽  
...  
Keyword(s):  
Adaptive Radiotherapy ◽  
Observer Variability ◽  
Inter Observer Variability ◽  
The Impact

scholarly journals The impact of 2D cine MR imaging parameters on automated tumor and organ localization for MR-guided real-time adaptive radiotherapy

2018 ◽  
Vol 63 (23) ◽  
pp. 235005 ◽  
Author(s):  
Martin J Menten ◽  
Martin F Fast ◽  
Andreas Wetscherek ◽  
Christopher M Rank ◽  
Marc Kachelrieß ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Real Time ◽  
Adaptive Radiotherapy ◽  
Imaging Parameters ◽  
Cine Mr ◽  
The Impact

scholarly journals Adaptive Radiotherapy for Glioblastoma Multiforme – The Impact on Disease Outcome

2020 ◽  
Vol 40 (8) ◽  
pp. 4237-4244
Author(s):  
ZOLTÁN VÉGVÁRY ◽  
BARBARA DARÁZS ◽  
VIKTOR PACZONA ◽  
ÁGNES DOBI ◽  
ZITA REISZ ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Adaptive Radiotherapy ◽  
Disease Outcome ◽  
The Impact

Formation of Lunar Craters and Bright Rays as a Result of Meteorite Impacts

1962 ◽  
Vol 14 ◽  
pp. 415-418
Author(s):  
K. P. Stanyukovich ◽  
V. A. Bronshten
Keyword(s):  
Explosive Charge ◽  
The Moon ◽  
Meteorite Impacts ◽  
The Earth ◽  
Lunar Craters ◽  
The Impact

The phenomena accompanying the impact of large meteorites on the surface of the Moon or of the Earth can be examined on the basis of the theory of explosive phenomena if we assume that, instead of an exploding meteorite moving inside the rock, we have an explosive charge (equivalent in energy), situated at a certain distance under the surface.

The Geosciences Applied to Lunar Exploration

1962 ◽  
Vol 14 ◽  
pp. 169-257 ◽  
Author(s):  
J. Green
Keyword(s):  
Lunar Surface ◽  
Probable Mechanism ◽  
Point Of View ◽  
Lunar Exploration ◽  
Geological Model ◽  
Apply Geophysics ◽  
Surface Features ◽  
The Impact

The term geo-sciences has been used here to include the disciplines geology, geophysics and geochemistry. However, in order to apply geophysics and geochemistry effectively one must begin with a geological model. Therefore, the science of geology should be used as the basis for lunar exploration. From an astronomical point of view, a lunar terrain heavily impacted with meteors appears the more reasonable; although from a geological standpoint, volcanism seems the more probable mechanism. A surface liberally marked with volcanic features has been advocated by such geologists as Bülow, Dana, Suess, von Wolff, Shaler, Spurr, and Kuno. In this paper, both the impact and volcanic hypotheses are considered in the application of the geo-sciences to manned lunar exploration. However, more emphasis is placed on the volcanic, or more correctly the defluidization, hypothesis to account for lunar surface features.

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