Surface Features of Recombinant Spider Silk Protein eADF4(κ16)‐Made Materials are Well‐Suited for Cardiac Tissue Engineering

2017 ◽  
Vol 27 (36) ◽  
pp. 1701427 ◽  
Author(s):  
Jana Petzold ◽  
Tamara B. Aigner ◽  
Filip Touska ◽  
Katharina Zimmermann ◽  
Thomas Scheibel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Spider Silk ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Silk Protein ◽  
Surface Features ◽  
Spider Silk Protein

scholarly journals Recombinant spider silk protein eADF4(C16)-RGD coatings are suitable for cardiac tissue engineering

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Johannes P. M. Kramer ◽  
Tamara B. Aigner ◽  
Jana Petzold ◽  
Kaveh Roshanbinfar ◽  
Thomas Scheibel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Spider Silk ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Silk Protein ◽  
Spider Silk Protein

scholarly journals Designing of spider silk proteins for hiPSC-based cardiac tissue engineering

2021 ◽  
pp. 100114
Author(s):  
Tilman U. Esser ◽  
Vanessa T. Trossmann ◽  
Sarah Lentz ◽  
Felix B. Engel ◽  
Thomas Scheibel
Keyword(s):  
Tissue Engineering ◽  
Spider Silk ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Silk Proteins

A Novel Scaffold from Recombinant Spider Silk Protein in Tissue Engineering

2010 ◽  
Vol 152-153 ◽  
pp. 1734-1744 ◽  
Author(s):  
Hong Xin Wang ◽  
Zheng Xiang Xue ◽  
Mei Hong Wei ◽  
Deng Long Chen ◽  
Min Li
Keyword(s):  
Tissue Engineering ◽  
Spider Silk ◽  
Silk Protein ◽  
Scaffold Material ◽  
3T3 Cells ◽  
Spider Silk Protein ◽  
Nih 3T3 ◽  
Novel Scaffold ◽  
Nih 3T3 Cells

As a new biomaterial, recombinant spider silk protein has attracted much attention in tissue engineering. The pNSR-16/ BL21(DE3)pLysS strains fermented and produced the recombinant spider silk protein, which was then cast into scaffolds. NIH-3T3 cells were cultivated with extractions of the scaffolds in vitro. The cytotoxicity of scaffolds was analyzed with a MTT assay. The performances of cells adhesion, growth and expression on the scaffolds were observed with SEM, HE staining and immunohistochemistry. Compared with the control, the extract fluid of materials culturing the NIH-3T3 cells was not apparently different. NIH-3T3 cells could adhere and grow on the scaffolds and secret FGF-2. The pNSR-16 recombinant spider silk protein scaffolds has satisfactory cytocompatibility and the scaffolds are ideal scaffold material for tissue engineering.

scholarly journals Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering

Biomaterials ◽  
2012 ◽  
Vol 33 (9) ◽  
pp. 2673-2680 ◽  
Author(s):  
Chinmoy Patra ◽  
Sarmistha Talukdar ◽  
Tatyana Novoyatleva ◽  
Siva R. Velagala ◽  
Christian Mühlfeld ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Silk Protein ◽  
Antheraea Mylitta

Three-dimensional scaffold made from recombinant spider silk protein for tissue engineering

2009 ◽  
Vol 426 (1) ◽  
pp. 127-130 ◽  
Author(s):  
I. I. Agapov ◽  
O. L. Pustovalova ◽  
M. M. Moisenovich ◽  
V. G. Bogush ◽  
O. S. Sokolova ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Spider Silk ◽  
Three Dimensional ◽  
Silk Protein ◽  
Spider Silk Protein

scholarly journals Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

Materials ◽  
2016 ◽  
Vol 9 (7) ◽  
pp. 560 ◽  
Author(s):  
John Hardy ◽  
Jose Torres-Rendon ◽  
Aldo Leal-Egaña ◽  
Andreas Walther ◽  
Helmut Schlaad ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Composite Materials ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Spider Silk ◽  
Silk Protein ◽  
Spider Silk Protein

scholarly journals Extrinsically Conductive Nanomaterials for Cardiac Tissue Engineering Applications

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 914
Author(s):  
Arsalan Ul Haq ◽  
Felicia Carotenuto ◽  
Paolo Di Nardo ◽  
Roberto Francini ◽  
Paolo Prosposito ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Scar Tissue ◽  
Cardiac Tissue Engineering ◽  
Assistive Device ◽  
Long Run ◽  
Fibrotic Scar ◽  
Regeneration Capability ◽  
Conductive Nanomaterials

Myocardial infarction (MI) is the consequence of coronary artery thrombosis resulting in ischemia and necrosis of the myocardium. As a result, billions of contractile cardiomyocytes are lost with poor innate regeneration capability. This degenerated tissue is replaced by collagen-rich fibrotic scar tissue as the usual body response to quickly repair the injury. The non-conductive nature of this tissue results in arrhythmias and asynchronous beating leading to total heart failure in the long run due to ventricular remodelling. Traditional pharmacological and assistive device approaches have failed to meet the utmost need for tissue regeneration to repair MI injuries. Engineered heart tissues (EHTs) seem promising alternatives, but their non-conductive nature could not resolve problems such as arrhythmias and asynchronous beating for long term in-vivo applications. The ability of nanotechnology to mimic the nano-bioarchitecture of the extracellular matrix and the potential of cardiac tissue engineering to engineer heart-like tissues makes it a unique combination to develop conductive constructs. Biomaterials blended with conductive nanomaterials could yield conductive constructs (referred to as extrinsically conductive). These cell-laden conductive constructs can alleviate cardiac functions when implanted in-vivo. A succinct review of the most promising applications of nanomaterials in cardiac tissue engineering to repair MI injuries is presented with a focus on extrinsically conductive nanomaterials.

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