Direct Synthesis of Pyrazolo[5,1‐ a ]isoindoles via Intramolecular Palladium‐Catalyzed CH Bond Activation

2010 ◽  
Vol 352 (11‐12) ◽  
pp. 2041-2049 ◽  
Author(s):  
Young Lok Choi ◽  
Hyuk Lee ◽  
Bum Tae Kim ◽  
Kihang Choi ◽  
Jung‐Nyoung Heo
Keyword(s):  
Bond Activation ◽  
Direct Synthesis ◽  
Palladium Catalyzed

ChemInform Abstract: Direct Synthesis of Pyrazolo[5,1-a]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation.

ChemInform ◽  
2010 ◽  
Vol 42 (3) ◽  
pp. no-no
Author(s):  
Young Lok Choi ◽  
Hyuk Lee ◽  
Bum Tae Kim ◽  
Kihang Choi ◽  
Jung-Nyoung Heo
Keyword(s):  
Bond Activation ◽  
Direct Synthesis ◽  
Palladium Catalyzed

Theoretical and experimental studies of palladium-catalyzed site-selective C(sp3)−H bond functionalization enabled by transient ligands

2017 ◽  
Author(s):  
Haibo Ge ◽  
Lei Pan ◽  
Piaoping Tang ◽  
Ke Yang ◽  
Mian Wang ◽  
...  
Keyword(s):  
Bond Activation ◽  
Theoretical Calculations ◽  
Experimental Studies ◽  
Bond Functionalization ◽  
Aliphatic Ketones ◽  
Site Selectivity ◽  
Mechanistic Investigation ◽  
Palladium Catalyzed ◽  
Metal Catalyzed ◽  
Site Selective

Transition metal-catalyzed selective C–H bond functionalization enabled by transient ligands has become an extremely attractive topic due to its economical and greener characteristics. However, catalytic pathways of this reaction process on unactivated sp<sup>3</sup> carbons of reactants have not been well studied yet. Herein, detailed mechanistic investigation on Pd-catalyzed C(sp<sup>3</sup>)–H bond activation with amino acids as transient ligands has been systematically conducted. The theoretical calculations showed that higher angle distortion of C(sp2)-H bond over C(sp3)-H bond and stronger nucleophilicity of benzylic anion over its aromatic counterpart, leading to higher reactivity of corresponding C(sp<sup>3</sup>)–H bonds; the angle strain of the directing rings of key intermediates determines the site-selectivity of aliphatic ketone substrates; replacement of glycine with β-alanine as the transient ligand can decrease the angle tension of the directing rings. Synthetic experiments have confirmed that β-alanine is indeed a more efficient transient ligand for arylation of β-secondary carbons of linear aliphatic ketones than its glycine counterpart.<br><br>

Palladium-Catalyzed C–C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides

2021 ◽  
Vol 86 (3) ◽  
pp. 2682-2695
Author(s):  
Tanmayee Nanda ◽  
Pragati Biswal ◽  
Bedadyuti Vedvyas Pati ◽  
Shyam Kumar Banjare ◽  
Ponneri Chandrababu Ravikumar
Keyword(s):  
Bond Activation ◽  
Unsaturated Esters ◽  
Palladium Catalyzed

Cu-catalyzed C–H Activation Reaction: One Pot Direct Synthesis of Xanthine and Uric Acid Derivatives from 5-Bromo Uracil

Synlett ◽  
2021 ◽  
Author(s):  
Habibur Rahaman ◽  
Brindaban Roy ◽  
Somjit Hazra ◽  
Biplab Mondal
Keyword(s):  
Uric Acid ◽  
Bond Activation ◽  
Direct Synthesis ◽  
One Pot ◽  
Activation Reaction

Abstract: A one pot direct synthesis of xanthine and uric acid derivates is reported. This simple yet efficient methodology illustrates concurrent formation of two C-N bonds using CuBr2 as catalyst and one of those C-N bonds is formed by uracil C6-H bond activation.

Palladium‐Catalyzed C‐C Bond Activation/Suzuki Reaction of Methylenecyclobutanes †

2021 ◽  
Author(s):  
Xiao‐Bing Chen ◽  
Li Li ◽  
Wan‐Chun Yang ◽  
Kun‐Long Song ◽  
Bin Wu ◽  
...  
Keyword(s):  
Bond Activation ◽  
Suzuki Reaction ◽  
Palladium Catalyzed

Pd(ii)-Catalyzed oxidative alkenylation of 4-hydroxycoumarin with maleimide via a C–H bond activation strategy

2021 ◽  
Author(s):  
Kumud Sharma ◽  
Kashmiri Neog ◽  
Abhilash Sharma ◽  
Pranjal Gogoi
Keyword(s):  
Bond Activation ◽  
Direct Synthesis

A Pd(ii)-catalyzed oxidative alkenylation of 4-hydroxycoumarins with maleimides has been developed for the direct synthesis of novel 4-hydroxy-3-maleimidecoumarins without prefunctionalization.

Direct Synthesis of Amino-substituted Aromatic Phosphonates via Palladium-catalyzed Coupling of Aromatic Mono- and Dibromides with Diethyl Phosphite

2009 ◽  
Vol 38 (7) ◽  
pp. 738-739 ◽  
Author(s):  
Alla Bessmertnykh ◽  
Christiane Morkos Douaihy ◽  
Roger Guilard
Keyword(s):  
Direct Synthesis ◽  
Diethyl Phosphite ◽  
Palladium Catalyzed

Palladium-catalyzed synthesis of aromatic acids from carbon monoxide and aromatic compounds via the aromatic CH bond activation

1990 ◽  
Vol 385 (2) ◽  
pp. 297-306 ◽  
Author(s):  
Tetsuro Jintoku ◽  
Yuzo Fujiwara ◽  
Itaru Kawata ◽  
Tomio Kawauchi ◽  
Hiroshi Taniguchi
Keyword(s):  
Carbon Monoxide ◽  
Aromatic Compounds ◽  
Bond Activation ◽  
Aromatic Acids ◽  
Palladium Catalyzed
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