Cross-coupling reactions are a fundamental tool in the large scale synthesis of pharma-, agro- and fine chemicals. Homogeneous palladium complexes remain the state-of-the-art catalysts even though the use of heterogeneous...
Background:
The synthesis of 5-arylation uracil nucleosides is an imperative challenge. Especially for the method of suzuki reaction using N-unprotected uracil as materials, which holds potential to enhance the yield.
Objective:
In order to find a more efficient catalyst to increase the yield of aryluracils and aryluridines.
Methods:
We first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material. And then prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of PAGC and Pa(OAc)2.
Results:
When using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine and aryl heterocyclic boronic acids. The arylation yields have been a significantly improvement.
Conclusion:
This means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for Suzuki arylation of 5-iodouracil and 5-iodouridine.
In this study, a series of N-heterocyclic indolyl ligand precursors 2-Py-Py-IndH, 2-Py-Pz-IndH, 2-Py-7-Py-IndH, 2-Py-7-Pz-IndH, and 2-Ox-7-Py-IndH (L1H-L5H) were prepared. The treatment of ligand precursors with 1 equivalent of palladium acetate affords palladium complexes 1–5. All ligand precursors and palladium complexes were characterized by NMR spectroscopy and elemental analysis. The molecular structures of complexes 3 and 5 were determined by single crystal X-ray diffraction techniques. The application of those palladium complexes 1–5 to the Suzuki reaction with aryl halide substrates was examined.
Preparation and characterization of Cu based on 2-(5-Aminopyrimidin-2-yl)pyrimidin-5-amine as novel recyclable metal-organic frameworks for Suzuki reaction
