scholarly journals Sexual Dimorphism of Gut Microbiota Dictates Therapeutics Efficacy of Radiation Injuries

2019 ◽  
Vol 6 (21) ◽  
pp. 1901048 ◽  
Author(s):  
Ming Cui ◽  
Huiwen Xiao ◽  
Yuan Li ◽  
Shuqin Zhang ◽  
Jiali Dong ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Gut Microbiota ◽  
Radiation Injuries

scholarly journals Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

Microbiome ◽  
2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Jordi Mayneris-Perxachs ◽  
María Arnoriaga-Rodríguez ◽  
Diego Luque-Córdoba ◽  
Feliciano Priego-Capote ◽  
Vicente Pérez-Brocal ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Gut Microbiota ◽  
Menopausal Status ◽  
Gonadal Steroids ◽  
Microbiota Composition ◽  
Gonadal Steroid ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Gut Microbiota Composition

Abstract Background Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the gonadal steroid status. Therefore, we investigated the gut microbiome composition and functionality in relation to sex, menopausal status, and circulating sex steroids. Results No significant differences were found in alpha diversity indices among pre- and post-menopausal women and men, but beta diversity differed among groups. The gut microbiota from post-menopausal women was more similar to men than to pre-menopausal women. Metagenome functional analyses revealed no significant differences between post-menopausal women and men. Gonadal steroids were specifically associated with these differences. Hence, the gut microbiota of pre-menopausal women was more enriched in genes from the steroid biosynthesis and degradation pathways, with the former having the strongest fold change among all associated pathways. Microbial steroid pathways also had significant associations with the plasma levels of testosterone and progesterone. In addition, a specific microbiome signature was able to predict the circulating testosterone levels at baseline and after 1-year follow-up. In addition, this microbiome signature could be transmitted from humans to antibiotic-induced microbiome-depleted male mice, being able to predict donor’s testosterone levels 4 weeks later, implying that the microbiota profile of the recipient mouse was influenced by the donor’s gender. Finally, obesity eliminated most of the differences observed among non-obese pre-menopausal women, post-menopausal women, and men in the gut microbiota composition (Bray-Curtis and weighted unifrac beta diversity), functionality, and the gonadal steroid status. Conclusions The present findings evidence clear differences in the gut microbial composition and functionality between men and women, which is eliminated by both menopausal and obesity status. We also reveal a tight link between the gut microbiota composition and the circulating levels of gonadal steroids, particularly testosterone.

scholarly journals Sexual dimorphism of gut microbiota at different pubertal status

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Xin Yuan ◽  
Ruimin Chen ◽  
Ying Zhang ◽  
Xiangquan Lin ◽  
Xiaohong Yang
Keyword(s):  
Sexual Dimorphism ◽  
Gut Microbiota ◽  
Pubertal Status

scholarly journals Sexual Dimorphism of Atherosclerosis by Gut Microbiome in a Hyperlipidemic Diversity Outbred F1 Mouse Population

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1569-1569
Author(s):  
Myungsuk Kim ◽  
M Nazmul Huda ◽  
Excel Que ◽  
Erik Gertz ◽  
Brian Bennett
Keyword(s):  
Sexual Dimorphism ◽  
Environmental Factors ◽  
Gut Microbiota ◽  
Plasma Cholesterol ◽  
Functional Characterization ◽  
Inbred Strains ◽  
Sexually Dimorphic ◽  
Mouse Population ◽  
Diversity Outbred ◽  
Α Diversity

Abstract Objectives Atherosclerosis is a complex multifactorial disease that develops through the interaction of various genetic and environmental factors. The environmental factors affecting atherosclerosis susceptibility include gender differences and the gut microbiota. However, the association between sex, microbiota, and atherosclerosis remains unclear. We hypothesized that the association between gut microbial profiles and atherosclerosis demonstrates sexual dimorphism. In order to test this hypothesis, we examined atherosclerosis and microbiota in a population of hyperlipidemic outbred mice. Methods We collected offspring (262 female and 269 male mice) from a cross between hyperlipidemic male C57BL/6J mice, transgenic for both human apolipoprotein E-Leiden and cholesterol ester transfer protein genes, and ∼200 female Diversity Outbred (DO) mice, a population derived from 8 inbred strains. We fed the offspring a high fat/cholesterol diet for 12 weeks. We then examined over 20 cardio-metabolic traits and their fecal microbiota compositions using 16S rRNA sequencing. Results Female mice were significantly more susceptible to atherosclerosis with higher lesion area (P < 0.0001) and plasma cholesterol (P < 0.0001) than males. For gut microbiota analysis, females had higher microbial α-diversity (Shannon diversity, P < 0.0001) than males and their β-diversity (Unweighted UniFrac, R2 = 0.01, PERMANOVA < 0.001) showed that the overall community is significantly different. We also examined the association between sexually-dimorphic gut phylotypes and cardiometabolic phenotypes and identified a negative correlation between atherosclerosis and the abundance of the genus Bifidobacterium, while abundances of genus Lactococcus were positively associated with atherosclerosis. Upcoming studies will be designed to identify host genes affecting microbiota abundance and functional characterization of specific microbiota-atherosclerosis traits. Conclusions To the best of our knowledge, this study suggests the first example of complex interactions between sexually dimorphic traits and gut microbiota associated with atherosclerosis using DO-F1 mice. Funding Sources This work was supported by the National Heart, Lung, and Blood Institute.

Gut microbiota contributes to sexual dimorphism in murine autoimmune cholangitis

2021 ◽  
Author(s):  
Meng‐Xing Huang ◽  
Si‐Yu Yang ◽  
Pan‐Yue Luo ◽  
Jie Long ◽  
Qing‐Zhi Liu ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Gut Microbiota ◽  
Autoimmune Cholangitis

scholarly journals ­­Age-Dependent Sexual Dimorphism in the Adult Human Gut Microbiota

2019 ◽  
Author(s):  
Xiuying Zhang ◽  
Huanzi Zhong ◽  
Yufeng Li ◽  
Zhun Shi ◽  
Zhe Zhang ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Gut Microbiota ◽  
Human Gut ◽  
Adult Human ◽  
Human Gut Microbiota ◽  
Age Dependent

Folate and vitamin B-12 deficiencies additively impaired memory function and disturbed the gut microbiota in amyloid-β infused rats

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Sunmin Park ◽  
Sunna Kang ◽  
Da Sol Kim
Keyword(s):  
Insulin Resistance ◽  
Gut Microbiota ◽  
Insulin Signaling ◽  
Gut Microbiome ◽  
Metabolic Diseases ◽  
Memory Function ◽  
Amyloid Β ◽  
Impaired Memory ◽  
Ca1 Region ◽  
Folate And Vitamin B12

Abstract. Folate and vitamin B12(V-B12) deficiencies are associated with metabolic diseases that may impair memory function. We hypothesized that folate and V-B12 may differently alter mild cognitive impairment, glucose metabolism, and inflammation by modulating the gut microbiome in rats with Alzheimer’s disease (AD)-like dementia. The hypothesis was examined in hippocampal amyloid-β infused rats, and its mechanism was explored. Rats that received an amyloid-β(25–35) infusion into the CA1 region of the hippocampus were fed either control(2.5 mg folate plus 25 μg V-B12/kg diet; AD-CON, n = 10), no folate(0 folate plus 25 μg V-B12/kg diet; AD-FA, n = 10), no V-B12(2.5 mg folate plus 0 μg V-B12/kg diet; AD-V-B12, n = 10), or no folate plus no V-B12(0 mg folate plus 0 μg V-B12/kg diet; AD-FAB12, n = 10) in high-fat diets for 8 weeks. AD-FA and AD-VB12 exacerbated bone mineral loss in the lumbar spine and femur whereas AD-FA lowered lean body mass in the hip compared to AD-CON(P < 0.05). Only AD-FAB12 exacerbated memory impairment by 1.3 and 1.4 folds, respectively, as measured by passive avoidance and water maze tests, compared to AD-CON(P < 0.01). Hippocampal insulin signaling and neuroinflammation were attenuated in AD-CON compared to Non-AD-CON. AD-FAB12 impaired the signaling (pAkt→pGSK-3β) and serum TNF-α and IL-1β levels the most among all groups. AD-CON decreased glucose tolerance by increasing insulin resistance compared to Non-AD-CON. AD-VB12 and AD-FAB12 increased insulin resistance by 1.2 and 1.3 folds, respectively, compared to the AD-CON. AD-CON and Non-AD-CON had a separate communities of gut microbiota. The relative counts of Bacteroidia were lower and those of Clostridia were higher in AD-CON than Non-AD-CON. AD-FA, but not V-B12, separated the gut microbiome community compared to AD-CON and AD-VB12(P = 0.009). In conclusion, folate and B-12 deficiencies impaired memory function by impairing hippocampal insulin signaling and gut microbiota in AD rats.

Sign in / Sign up

Export Citation Format

Share Document