Short period of administration of diethylstilbestrol in stuttering priapism in sickle cell anemia

ABSTRACT Objective: To determine the serum levels of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea in outpatient's setting. Methods: Of the 65 patients with sickle cell anemia selected for the study, 51 were not treated with hydroxyurea (Group 1), 14 made chronic use of hydroxyurea (Group 2) and 20 individuals had no hemoglobinopathies (Control Group). Results: The Control Group had a lower and more homogeneous concentration of malondialdehyde levels as compared to the other groups. The results of Groups 1 and 2 showed increased values of malondialdehyde levels when compared to the Control Group. Considering the values of Groups 1 and 2, there were no significant changes in the malondialdehyde levels. There was no significant difference in the serum levels of nitrite between the groups. Group 2 presented a statistically significant correlation between serum malondialdehyde levels and the clinical variables investigated. In turn, Group 1 showed correlation only with occurrence of three or more vaso-occlusive crises. There was no correlation between nitrite levels and the clinical variables. Conclusion: The results revealed that during the pathogenesis of sickle cell anemia, an increase in lipid peroxidation was observed. On the other hand, no changes in oxidative parameters were detected during treatment with hydroxyurea, probably due to the short period of treatment of the patients studied.

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A Prospective Diary Study of Stuttering Priapism in Adolescents and Young Men With Sickle Cell Anemia: Report of an International Randomized Control Trial--The Priapism in Sickle Cell Study

Journal of Andrology ◽

10.2164/jandrol.110.010934 ◽

2010 ◽

Vol 32 (4) ◽

pp. 375-382 ◽

Cited By ~ 30

Author(s):

A. B. Olujohungbe ◽

A. Adeyoju ◽

A. Yardumian ◽

O. Akinyanju ◽

J. Morris ◽

...

Keyword(s):

Sickle Cell ◽

Sickle Cell Anemia ◽

Randomized Control Trial ◽

Young Men ◽

Diary Study ◽

Randomized Control ◽

Stuttering Priapism ◽

Cell Study

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Re: A Prospective Diary Study of Stuttering Priapism in Adolescents and Young Men With Sickle Cell Anemia: Report of an International Randomized Control Trial; the Priapism in Sickle Cell Study (PISCES study)

The Journal of Urology ◽

10.1016/s0022-5347(11)60219-x ◽

2011 ◽

Vol 185 (5) ◽

pp. 1837-1838 ◽

Cited By ~ 2

Author(s):

Allen D. Seftel

Keyword(s):

Sickle Cell ◽

Sickle Cell Anemia ◽

Randomized Control Trial ◽

Young Men ◽

Diary Study ◽

Randomized Control ◽

Stuttering Priapism ◽

Cell Study

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The orientation of sickle hemoglobin fibers within fascicles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100104066 ◽

1988 ◽

Vol 46 ◽

pp. 400-401

Author(s):

Christopher A. Miller ◽

Bridget Carragher ◽

William A. McDade ◽

Robert Josephs

Keyword(s):

Sickle Cell ◽

Sickle Cell Anemia ◽

Relative Orientation ◽

Unit Cell ◽

Red Cell ◽

High Ph ◽

Sickle Hemoglobin ◽

Polar Crystal ◽

Helical Configuration

Highly ordered bundles of deoxyhemoglobin S (HbS) fibers, termed fascicles, are intermediates in the high pH crystallization pathway of HbS. These fibers consist of 7 Wishner-Love double strands in a helical configuration. Since each double strand has a polarity, the odd number of double strands in the fiber imparts a net polarity to the structure. HbS crystals have a unit cell containing two double strands, one of each polarity, resulting in a net polarity of zero. Therefore a rearrangement of the double strands must occur to form a non-polar crystal from the polar fibers. To determine the role of fascicles as an intermediate in the crystallization pathway it is important to understand the relative orientation of fibers within fascicles. Furthermore, an understanding of fascicle structure may have implications for the design of potential sickling inhibitors, since it is bundles of fibers which cause the red cell distortion responsible for the vaso-occlusive complications characteristic of sickle cell anemia.

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