scholarly journals Unusual inclusions in hemoglobin H disease post-splenectomy

2018 ◽  
Vol 93 (7) ◽  
pp. 963-964 ◽  
Author(s):  
Michael Spencer-Chapman ◽  
Asad Luqmani ◽  
D. Mark Layton ◽  
Barbara J. Bain
Keyword(s):  
Hemoglobin H Disease

Hemoglobin H disease: not necessarily a benign disorder

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 791-800 ◽  
Author(s):  
David H. K. Chui ◽  
Suthat Fucharoen ◽  
Vivian Chan
Keyword(s):  
Benign Disorder ◽  
Hemoglobin H Disease

Optimizing the Detection of Hemoglobin H Disease

1995 ◽  
Vol 26 (11) ◽  
pp. 736-742 ◽  
Author(s):  
Robert B. Hall ◽  
Jo A. Haga ◽  
Cynthia G. Guerra ◽  
Silvia M. Castleberry ◽  
John R. Hickman
Keyword(s):  
Hemoglobin H Disease

Hemoglobin H disease in two Iranian families

1968 ◽  
Vol 20 (3) ◽  
pp. 381-385 ◽  
Author(s):  
S. Rahbar
Keyword(s):  
Hemoglobin H Disease

Hemoglobin H Disease and Mental Retardation

1981 ◽  
Vol 305 (11) ◽  
pp. 607-612 ◽  
Author(s):  
D. J. Weatherall ◽  
D. R. Higgs ◽  
C. Bunch ◽  
J. M. Old ◽  
D. M. Hunt ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Hemoglobin H Disease

scholarly journals Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease

Blood ◽  
1996 ◽  
Vol 88 (5) ◽  
pp. 1846-1851 ◽  
Author(s):  
J Chang ◽  
RH Lu ◽  
SM Xu ◽  
J Meneses ◽  
K Chan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mouse Model ◽  
Knockout Mice ◽  
Globin Gene ◽  
Embryonic Stem ◽  
Globin Genes ◽  
Human Homologue ◽  
Alpha Thalassemia ◽  
Alpha Globin ◽  
Hemoglobin H Disease

We have disrupted the 5′ locus of the duplicated adult alpha-globin genes by gene targeting in the mouse embryonic stem cells and created mice with alpha-thalassemia syndromes. The heterozygous knockout mice (.alpha/alpha alpha) are asymptomatic like the silent carriers in humans whereas the homozygous knockout mice (.alpha/.alpha) show hemolytic anemia. Mice with three dysfunctional alpha-globin genes generated by breeding the 5′ alpha-globin knockouts (.alpha/alpha alpha) and the deletion type alpha-thalassemia mice (../alpha alpha) produce severe hemoglobin H disease and they die in utero. These results indicate that the 5′ alpha-globin gene is the predominant locus in mice, and suggest that it is even more dominant than its human homologue.

scholarly journals A 6-year-old Girl with Hemoglobin H Disease

2011 ◽  
Vol 78 (2) ◽  
pp. 101-104
Author(s):  
Takahiro Ueda ◽  
Makoto Migita ◽  
Miho Yamanishi ◽  
Miho Maeda ◽  
Keiko Harano ◽  
...  
Keyword(s):  
Hemoglobin H Disease

Iranian patients with hemoglobin H disease: genotype–phenotype correlation

2019 ◽  
Vol 46 (5) ◽  
pp. 5041-5048 ◽  
Author(s):  
Mostafa Paridar ◽  
Ebrahim Azizi ◽  
Bijan Keikhaei ◽  
Vahideh Takhviji ◽  
Iman Baluchi ◽  
...  
Keyword(s):  
Phenotype Correlation ◽  
Genotype Phenotype Correlation ◽  
Iranian Patients ◽  
Hemoglobin H Disease

Early development of decreased β‐cell insulin secretion in children and adolescents with hemoglobin H disease and its relationship with levels of anemia

2019 ◽  
Vol 67 (4) ◽  
Author(s):  
Pairunyar Nakavachara ◽  
Worarat Kajchamaporn ◽  
Julaporn Pooliam ◽  
Vip Viprakasit
Keyword(s):  
Insulin Secretion ◽  
Children And Adolescents ◽  
Early Development ◽  
Β Cell ◽  
Hemoglobin H Disease

An Unusual Case of Hemoglobin Bart's Hydrops Fetalis

1975 ◽  
Vol 24 (1-2) ◽  
pp. 97-103 ◽  
Author(s):  
I. Halbrecht ◽  
F. Shabtai
Keyword(s):  
Unusual Case ◽  
Hydrops Fetalis ◽  
Alpha Chain ◽  
Total Hemoglobin ◽  
Alpha Thalassemia ◽  
Chain Locus ◽  
Hemoglobin H Disease

A baby with alpha-chain thalassemia hydrops fetalis was born to an Iraqian Jewish couple of Iraqi-Kurdish extraction. Hemoglobin Bart's constituted only 40% of the total hemoglobin, much less than usually found in alpha-thalassemia hydrops fetalis.That this is a particular expression of hemoglobin H disease is considered. The likelihood of two alpha-chain loci, rather than one alpha-chain locus, in this family, is also discussed.

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