Hemoglobin H disease: not necessarily a benign disorder

Blood ◽  
2003 ◽  
Vol 101 (3) ◽  
pp. 791-800 ◽  
Author(s):  
David H. K. Chui ◽  
Suthat Fucharoen ◽  
Vivian Chan
Keyword(s):  
Benign Disorder ◽  
Hemoglobin H Disease

Optimizing the Detection of Hemoglobin H Disease

1995 ◽  
Vol 26 (11) ◽  
pp. 736-742 ◽  
Author(s):  
Robert B. Hall ◽  
Jo A. Haga ◽  
Cynthia G. Guerra ◽  
Silvia M. Castleberry ◽  
John R. Hickman
Keyword(s):  
Hemoglobin H Disease

Anorexia Nervosa

1982 ◽  
Vol 4 (4) ◽  
pp. 123-129
Author(s):  
Hans Steiner
Keyword(s):  
Differential Diagnosis ◽  
Anorexia Nervosa ◽  
High Mortality ◽  
Early Identification ◽  
Aggressive Treatment ◽  
Adolescent Women ◽  
Benign Disorder ◽  
Long Run ◽  
Medical Symptoms

Anorexia nervosa is a complex, chronic, remittent disorder of mostly adolescent women. It presents with multiple psychiatric and medical symptoms which are difficult to diagnose and treat, especially in the long run. Its differential diagnosis is complex and treatment requires dedicated effort and several specialists working cooperatively. Its etiology is still unclear, although there are several promising leads. Treatment is largely empirical and nonspecific at this point. Early identification and aggressive treatment are the only hope for preventing chronicity. Its relatively high mortality attests to the fact that it is not a benign disorder.

Hemoglobin H disease in two Iranian families

1968 ◽  
Vol 20 (3) ◽  
pp. 381-385 ◽  
Author(s):  
S. Rahbar
Keyword(s):  
Hemoglobin H Disease

Hemoglobin H Disease and Mental Retardation

1981 ◽  
Vol 305 (11) ◽  
pp. 607-612 ◽  
Author(s):  
D. J. Weatherall ◽  
D. R. Higgs ◽  
C. Bunch ◽  
J. M. Old ◽  
D. M. Hunt ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Hemoglobin H Disease

scholarly journals Management of Recurrent Respiratory Papillomatosis: Current Status

2011 ◽  
Vol 1 (1) ◽  
pp. 33-36
Author(s):  
KK Handa ◽  
TB Shashidhar
Keyword(s):  
Recurrent Respiratory Papillomatosis ◽  
Current Status ◽  
Benign Disorder

ABSTRACT Recurrent respiratory papillomatosis is benign disorder which affects children and requires long-term multiple surgical extirpations. The authors present their experience of different techniques in 35 patients and the literature is reviewed.

scholarly journals Case Report: A rare cause of oral bullae: Angina bullosa hemorrhagica

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1974 ◽  
Author(s):  
Salih Levent Cinar ◽  
Demet Kartal ◽  
Özlem Canöz ◽  
Murat Borlu ◽  
Ayten Ferahbas
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Hematological Disorders ◽  
Benign Disorder ◽  
Proper Diagnosis ◽  
Rule Out

Angina bullosa hemorrhagica (ABH) is a benign disorder of the oral cavity. Clinically, oral, blood-filled blisters are seen. To give a proper diagnosis, one should rule out any other cause. We aim to present this case in order to emphasize this rare cause of oral bullae which is necessary to be differentiated from many serious dermatological and hematological disorders.

scholarly journals A Rare Case of Vulvar and Umbilical Endometriosis in a Single Patient: A Case Report

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Pathiraja PDM ◽  
◽  
Ranaraja SK ◽  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Histopathological Examination ◽  
Single Patient ◽  
Benign Disorder ◽  
Ectopic Endometrium ◽  
Umbilical Endometriosis

Endometriosis is a benign disorder and characterized by ectopic endometrium like tissues outside the uterus. We report a case of a 31 year-old woman referred to our clinic due to complaints of a vulvar and umbilical mass and periodic swelling with pain of the mass at the time of menstruation. The cyst was removed totally. Histopathological examination showed findings compatible with endometriosis in both. We have treated them with suppressive treatment with Depot Medroxy Progesterone Acetate (DMPA) and after six months patient was completely asymptomatic.

scholarly journals Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease

Blood ◽  
1996 ◽  
Vol 88 (5) ◽  
pp. 1846-1851 ◽  
Author(s):  
J Chang ◽  
RH Lu ◽  
SM Xu ◽  
J Meneses ◽  
K Chan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mouse Model ◽  
Knockout Mice ◽  
Globin Gene ◽  
Embryonic Stem ◽  
Globin Genes ◽  
Human Homologue ◽  
Alpha Thalassemia ◽  
Alpha Globin ◽  
Hemoglobin H Disease

We have disrupted the 5′ locus of the duplicated adult alpha-globin genes by gene targeting in the mouse embryonic stem cells and created mice with alpha-thalassemia syndromes. The heterozygous knockout mice (.alpha/alpha alpha) are asymptomatic like the silent carriers in humans whereas the homozygous knockout mice (.alpha/.alpha) show hemolytic anemia. Mice with three dysfunctional alpha-globin genes generated by breeding the 5′ alpha-globin knockouts (.alpha/alpha alpha) and the deletion type alpha-thalassemia mice (../alpha alpha) produce severe hemoglobin H disease and they die in utero. These results indicate that the 5′ alpha-globin gene is the predominant locus in mice, and suggest that it is even more dominant than its human homologue.

scholarly journals Scrotal Calcinosis: A Case Report and Review of Pathogenesis and Surgical Management

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Usman M. Tela ◽  
M. Bashir Ibrahim
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Rare Disease ◽  
Surgical Management ◽  
Treatment Options ◽  
Wide Excision ◽  
Scrotal Skin ◽  
Direct Closure ◽  
Benign Disorder ◽  
Skin Nodules

Idiopathic scrotal calcinosis is an uncommon benign disorder of the scrotal skin which is characterized by multiple calcified intradermal nodules. We report a 33-year old with asymptomatic multiple calcified scrotal skin nodules. He had wide excision of the lesions and direct closure of the scrotum. We review the pathogenesis and surgical treatment options for this rare disease of the scrotum.

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