Novel Aza‐Michael Addition‐Asymmetric Protonation to α,β‐Unsaturated Carboxylic Acids with Chiral Thiourea‐Boronic Acid Hybrid Catalysts

2021 ◽  
Author(s):  
Hiroki Murakami ◽  
Ayano Yamada ◽  
Kenichi Michigami ◽  
Yoshiji Takemoto
Keyword(s):  
Carboxylic Acids ◽  
Michael Addition ◽  
Boronic Acid ◽  
Hybrid Catalysts ◽  
Unsaturated Carboxylic Acids

scholarly journals A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst

2020 ◽  
Vol 11 (21) ◽  
pp. 5572-5576 ◽  
Author(s):  
Noboru Hayama ◽  
Yusuke Kobayashi ◽  
Eriko Sekimoto ◽  
Anna Miyazaki ◽  
Kiyofumi Inamoto ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Tertiary Amine ◽  
Michael Addition ◽  
Arylboronic Acid ◽  
Unsaturated Carboxylic Acids

An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported.

scholarly journals Mechanistic Insight into Asymmetric Hetero-Michael Addition of α,β-Unsaturated Carboxylic Acids Catalyzed by Multifunctional Thioureas

2018 ◽  
Vol 140 (38) ◽  
pp. 12216-12225 ◽  
Author(s):  
Noboru Hayama ◽  
Ryuta Kuramoto ◽  
Tamás Földes ◽  
Kazuya Nishibayashi ◽  
Yusuke Kobayashi ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Michael Addition ◽  
Mechanistic Insight ◽  
Unsaturated Carboxylic Acids ◽  
Insight Into
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