It has been possible, by employing a new color reaction for methylpentoses, to determine the fucose content of individual hog and human blood group A, B, and O substances. The data indicate an inverse correlation between fucose content of the hog A and O substances and ability to cross-react with Type XIV antipneumococcus serum. The human A, B, and O substances display no correlation between their fucose content and ability to cross-react with Type XIV antipneumococcus serum.
Analyses of specific precipitates of hog and human blood group A substances for the amount of fucose precipitable by antibody have shown, that with certain preparations, essentially all of the fucose of the blood group substance is precipitated.
AbstractBackgroundBlood groups form the basis of effective and safe blood transfusion. There are about 41 well recognized human blood group systems presently known. Blood groups are molecularly determined by the presence of specific antigens on the red blood cells and are genetically determined and inherited following Mendelian principles. The lack of a comprehensive, relevant, manually compiled and genome-ready dataset of red cell antigens limited the widespread application of genomic technologies to characterise and interpret the blood group complement of an individual from genomic datasets.Materials and MethodsA range of public datasets were used to systematically annotate the variation compendium for its functionality and allele frequencies across global populations. Details on phenotype or relevant clinical importance were collated from reported literature evidence.ResultsWe have compiled the Blood Group Associated Genomic Variant Resource (BGvar), a manually curated online resource comprising all known human blood group related allelic variants including a total of 1672 ISBT approved alleles and 1552 alleles predicted and curated from literature reports. This repository includes 1606 Single Nucleotide Variations (SNVs), 270 Insertions, Deletions (InDels) and Duplications and about 1310 combination mutations corresponding to 41 human blood group systems and 2 transcription factors. This compendium also encompasses gene fusion and rearrangement events occurring in human blood group genes.ConclusionTo the best of our knowledge, BGvar is a comprehensive and a user friendly resource with most relevant collation of blood group alleles in humans. BGvar is accessible online at URL: http://clingen.igib.res.in/bgvar/
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS