scholarly journals Cognitive reserve among potentially inappropriate medication users with and without preclinical Alzheimer’s disease

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Ashley I. Martinez ◽  
Gregory A. Jicha ◽  
Riham H. El Khouli ◽  
Frederick A. Schmitt ◽  
Erin L. Abner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Reserve ◽  
Inappropriate Medication ◽  
Potentially Inappropriate Medication ◽  
Preclinical Alzheimer’S Disease

scholarly journals Potentially inappropriate medication use in older adults with mild-moderate Alzheimer’s disease: prevalence and associations with adverse events

2020 ◽  
Vol 49 (4) ◽  
pp. 580-587
Author(s):  
Claire Murphy ◽  
Adam H Dyer ◽  
Brian Lawlor ◽  
Sean P Kennelly ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Adverse Events ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Inappropriate Medication ◽  
Potentially Inappropriate Medication ◽  
Randomised Control Trial ◽  
Vulnerable Group ◽  
Serious Adverse Events

Abstract Aim Potentially inappropriate medication (PIM) use is prevalent in older adults and is associated with adverse events, hospitalisation and mortality. We assessed the patterns and associations of PIM use in older adults with mild-to-moderate Alzheimer’s Disease (AD), who may represent a particularly vulnerable group. Design Analysis of data from NILVad, an 18-month Randomised Control Trial of Nilvadapine in mild-to-moderate AD. The v2 STOPP criteria were applied in duplicate to identify PIM use. Associations between PIM use and adverse events/unscheduled healthcare visits in addition to the associations between PIM use and AD progression were evaluated. Setting and Participants 448 older adults with mild-to-moderate AD from 23 centres in nine European countries. Results Of 448 participants (mean age: 72.56 ± 8.19 years), over half (55.8%) were prescribed a PIM with 30.1% being prescribed 2+ PIMs. The most frequent PIMs were (i) long-term benzodiazepines (11.6% N = 52/448), (ii) selective serotonin reuptake inhibitors without appropriate indication (11.1% N = 50/448), and (iii) Proton-Pump Inhibitors (PPIs) without appropriate indication (10.7% N = 48/448). Increasing number of PIMs was associated with a greater risk of adverse events (IRR 1.17, 1.13–1.19, P < 0.001), serious adverse events (IRR 1.27; 1.17–1.37, P < 0.001), unscheduled hospitalisations (IRR 1.16, 1.03–1.30, P = 0.016) and GP visits (IRR 1.22, 1.15–1.28, P < 0.001). PIM use was not associated with dementia progression. Conclusions and Implications PIM use is highly prevalent in mild-to-moderate AD and is associated with adverse events and unscheduled healthcare utilisation. Further attention to de-prescribing in this vulnerable group is warranted.

[P4-109]: EFFECT OF COGNITIVE RESERVE ON TAU BURDEN IN PRECLINICAL ALZHEIMER's DISEASE

2017 ◽  
Vol 13 (7S_Part_27) ◽  
pp. P1299-P1299
Author(s):  
Sara Trombella ◽  
Giovanni B. Frisoni ◽  
Valentina Garibotto ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Reserve ◽  
Preclinical Alzheimer’S Disease

scholarly journals P2-572: INAPPROPRIATE MEDICATION USE ASSOCIATED WITH LOWER COGNITIVE RESERVE IN INDIVIDUALS WITH PRE-CLINICAL ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P842-P842
Author(s):  
Ashley I. Martinez ◽  
Brooke F. Beech ◽  
Erin L. Abner ◽  
Gregory A. Jicha ◽  
Frederick A. Schmitt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Reserve ◽  
Inappropriate Medication ◽  
Medication Use ◽  
Inappropriate Medication Use

scholarly journals Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer’s disease

2013 ◽  
Vol 4 (3-4) ◽  
pp. 136-142 ◽  
Author(s):  
Corinne Pettigrew ◽  
Anja Soldan ◽  
Shanshan Li ◽  
Yi Lu ◽  
Mei-Cheng Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Reserve ◽  
Clinical Symptoms ◽  
Preclinical Alzheimer’S Disease ◽  
Relationship Of

scholarly journals Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer's disease

2017 ◽  
Vol 60 ◽  
pp. 164-172 ◽  
Author(s):  
Anja Soldan ◽  
Corinne Pettigrew ◽  
Qing Cai ◽  
Jiangxia Wang ◽  
Mei-Cheng Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Reserve ◽  
Preclinical Alzheimer’S Disease ◽  
Term Change

P1-501: PATHOLOGIC ASSOCIATIONS OF POTENTIALLY INAPPROPRIATE MEDICATION USE IN PATIENTS WITH ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_9) ◽  
pp. P522-P522
Author(s):  
Paran Davari ◽  
Brooke F. Beech ◽  
Erin L. Abner ◽  
Ashley I. Martinez ◽  
Clark Kebodeaux ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inappropriate Medication ◽  
Medication Use ◽  
Potentially Inappropriate Medication ◽  
Inappropriate Medication Use
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