Cerebral metabolism and atrophy in huntington's disease determined by18FDG and computed tomographic scan

1982 ◽  
Vol 12 (5) ◽  
pp. 425-434 ◽  
Author(s):  
David E. Kuhl ◽  
Michael E. Phelps ◽  
Charles H. Markham ◽  
E. Jeffrey Metter ◽  
Walter H. Riege ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cerebral Metabolism ◽  
Computed Tomographic ◽  
Computed Tomographic Scan

Computed Tomographic, Neurologic, and Neuropsychological Correlates of Huntington'S Disease

1983 ◽  
Vol 18 (1-2) ◽  
pp. 21-36 ◽  
Author(s):  
Daniel S. Sax ◽  
Brian O'donnell ◽  
Nelson Butters ◽  
Leon Menzer ◽  
Kathleen Montgomery ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Computed Tomographic ◽  
Neuropsychological Correlates

A Primate Model of Huntington'S Disease: Functional Neural Transplantation and Ct-Guided Stereotactic Procedures

1992 ◽  
Vol 1 (4) ◽  
pp. 313-322 ◽  
Author(s):  
James M. Schumacher ◽  
Philippe Hantraye ◽  
Anna-Lisa Brownell ◽  
Danielle Riche ◽  
Bertha K. Madras ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Behavioral Model ◽  
Fetal Tissue ◽  
Primate Model ◽  
Ct Guided ◽  
Computed Tomographic ◽  
Positron Emission ◽  
Motor Movements ◽  
Stereotactic Implantation

In this article, we show that 1) computed tomographic (CT)-guided stereotactic infusion of an excitotoxin into the striatum of a nonhuman primate provides a useful neuropathologic and behavioral model for Huntington's disease. 2) High-resolution positron emission tomography (PET) can be used to image the decreased glucose utilization and the preservation of dopaminergic terminals in the lesioned striatum by using 2-fluoro-deoxy-D-glucose (2FDG) and N-(C-11)-methyl-2-beta-carbomethoxy-3-beta-phenyl tropane (CPT) as tracers. 3) Transplantation of crossspecies striatal fetal tissue into the lesioned caudate-putamen reduces many of the abnormal motor movements and behavioral changes seen in the Huntington's disease primate model. 4) Graft rejection results in the return of the abnormal signs of the pregrafted state. These results indicate that treatment of the neuronal deficit in Huntington's disease can involve intervention at the local neuronal circuit level. CT-guided stereotactic implantation of cells that might protect or replace this defective circuitry may eventually provide an effective treatment for Huntington's disease.

scholarly journals Structural Correlates of Neurological Signs in Huntington’s Disease: A Quantitative Approach

1994 ◽  
Vol 7 (3-4) ◽  
pp. 127-134 ◽  
Author(s):  
E. A. Loh ◽  
J. K. A. Roberts ◽  
E. Mohr
Keyword(s):  
Basal Ganglia ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Structural Changes ◽  
Third Ventricle ◽  
Strongly Correlated ◽  
Caudate Nuclei ◽  
Computed Tomographic ◽  
The Third ◽  
Motor Abnormality

Huntington's disease (HD) is a genetically transmitted disorder associated with atrophy of the basal ganglia. Studies of the neuroanatomical correlates of HD have focused primarily on the anterior areas of the basal ganglia and on establishing an association between structural changes resulting from the presence and course of the illness. The objective of the present study was to assess the value of measurements of the third ventrical and lentiform regions. Computed tomographic (CT) brain scan measures of the basal ganglia of patients in the “early” and “late” stages of the disease were correlated with scores on a quantified neurological examination (QNE) and compared with scans of age-matched control groups. Basal ganglia atrophy was assessed by two conventional “anterior” measures: the maximal distance between the frontal horns of the lateral ventricles (FH) and the minimum distance between the caudate nuclei (CC), and two measures of more “posterior” regions: the width of the third ventricle (3V), and a measure of the lentiform regions (LENTI). In the group of patients with HD, CT scan measures were strongly correlated with disease duration. Further, in the “late” group, all CT measures were significantly correlated with QNE scores, with the two “posterior” measures being equally, if not more strongly correlated with QNE scores than the conventional “anterior” measures. Separate correlations of the CT indices of atrophy and QNE scores in the “early” and “late” HD groups revealed relationships between basal ganglia atrophy and motor abnormality consistent with earlier reports.

Memory Processes in Huntington's Disease

2007 ◽  
Author(s):  
John McDowall ◽  
Kristy Bolter
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Memory Processes
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