Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis

2016 ◽  
Vol 128 (28) ◽  
pp. 8240-8244 ◽  
Author(s):  
Suman Kumar Maity ◽  
Muhammad Jbara ◽  
Shay Laps ◽  
Ashraf Brik
Keyword(s):  
Protein Synthesis ◽  
Native Chemical Ligation ◽  
One Pot ◽  
Chemical Ligation ◽  
Chemical Protein Synthesis

Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof

2019 ◽  
Vol 37 (11) ◽  
pp. 1181-1193 ◽  
Author(s):  
Siyao Wang ◽  
Yogesh Abaso Thopate ◽  
Qingqing Zhou ◽  
Ping Wang
Keyword(s):  
Protein Synthesis ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Chemical Protein Synthesis

One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1

2014 ◽  
Vol 50 (44) ◽  
pp. 5837-5839 ◽  
Author(s):  
Man Pan ◽  
Yao He ◽  
Ming Wen ◽  
Fangming Wu ◽  
Demeng Sun ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Snake Venom ◽  
Structure Determination ◽  
Native Chemical Ligation ◽  
One Pot ◽  
Chemical Ligation ◽  
Venom Toxin ◽  
Snake Venom Toxin ◽  
Switch Strategy

An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation.

scholarly journals A synthetic approach to ‘click’ neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry

2019 ◽  
Vol 10 (3) ◽  
pp. 815-828 ◽  
Author(s):  
D. J. Lee ◽  
A. J. Cameron ◽  
T. H. Wright ◽  
P. W. R. Harris ◽  
M. A. Brimble
Keyword(s):  
Native Chemical Ligation ◽  
Synthetic Approach ◽  
One Pot ◽  
Chemical Ligation ◽  
Synthetic Methodologies

The batch-wise variability of commercial erythropoietin (EPO) preparations warrants development of more advanced synthetic methodologies. We have developed a diverse chemical toolkit to prepare ‘click’ neoglycoprotein variants of EPO.

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