Azaphilones as Activation‐Free Primary‐Amine‐Specific Bioconjugation Reagents for Peptides, Proteins and Lipids

2021 ◽  
Author(s):  
Shandong Yi ◽  
Siyuan Wei ◽  
Qingsong Wu ◽  
Huan Wang ◽  
Zhu-Jun Yao
Keyword(s):  
Primary Amine

Regio-, Stereo- and Enantioselective α-Addition of Carbonyl Nucleo-philes to Allenamides Catalyzed by a Synergistic Copper/Enamine System

2020 ◽  
Author(s):  
Rémi Blieck ◽  
Sebastien Lemouzy ◽  
Marc Taillefer ◽  
Florian Monnier
Keyword(s):  
Catalytic System ◽  
Secondary Amine ◽  
Primary Amine ◽  
Synergistic Catalysis ◽  
Enantioselective Addition ◽  
Amine Catalysts

A dual copper/enamine catalytic system is found to enable an intermolecular enantioselective α-addition of various carbonyl nucleophiles to allenamides. Secondary amine catalysts allowed the highly enantioselective addition of aldehydes, while using primary amine catalysts led to the enantioselective addition of ketoester nucleophiles. The process was found to be highly regio-, stereo- and enantio-selective and represented the first allene hydrofunctionalization using an synergistic catalysis involving copper

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones

2016 ◽  
Vol 81 (6) ◽  
pp. 2420-2431 ◽  
Author(s):  
G. Madhusudhan Reddy ◽  
Chi-Ting Ko ◽  
Kai-Hong Hsieh ◽  
Chia-Jui Lee ◽  
Utpal Das ◽  
...  
Keyword(s):  
Primary Amine ◽  
Stereoselective Synthesis ◽  
Amine Catalysis

Asymmetric Sulfa-Michael Addition to α-Substituted Vinyl Ketones Catalyzed by Chiral Primary Amine

2014 ◽  
Vol 16 (17) ◽  
pp. 4626-4629 ◽  
Author(s):  
Niankai Fu ◽  
Long Zhang ◽  
Sanzhong Luo ◽  
Jin-Pei Cheng
Keyword(s):  
Michael Addition ◽  
Primary Amine

Highly enantioselective Michael-aldol-dehydration reaction for the synthesis of chiral 3,5-diaryl-cyclohexenones catalyzed by primary amine

Tetrahedron ◽  
2017 ◽  
Vol 73 (8) ◽  
pp. 1114-1119 ◽  
Author(s):  
Li Tang ◽  
Yuan Luo ◽  
Jing-Wen Xue ◽  
Yan-Hong He ◽  
Zhi Guan
Keyword(s):  
Primary Amine ◽  
Dehydration Reaction
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