Highly enantioselective Michael-aldol-dehydration reaction for the synthesis of chiral 3,5-diaryl-cyclohexenones catalyzed by primary amine

Tetrahedron ◽  
2017 ◽  
Vol 73 (8) ◽  
pp. 1114-1119 ◽  
Author(s):  
Li Tang ◽  
Yuan Luo ◽  
Jing-Wen Xue ◽  
Yan-Hong He ◽  
Zhi Guan
Keyword(s):  
Primary Amine ◽  
Dehydration Reaction

Regio-, Stereo- and Enantioselective α-Addition of Carbonyl Nucleo-philes to Allenamides Catalyzed by a Synergistic Copper/Enamine System

2020 ◽  
Author(s):  
Rémi Blieck ◽  
Sebastien Lemouzy ◽  
Marc Taillefer ◽  
Florian Monnier
Keyword(s):  
Catalytic System ◽  
Secondary Amine ◽  
Primary Amine ◽  
Synergistic Catalysis ◽  
Enantioselective Addition ◽  
Amine Catalysts

A dual copper/enamine catalytic system is found to enable an intermolecular enantioselective α-addition of various carbonyl nucleophiles to allenamides. Secondary amine catalysts allowed the highly enantioselective addition of aldehydes, while using primary amine catalysts led to the enantioselective addition of ketoester nucleophiles. The process was found to be highly regio-, stereo- and enantio-selective and represented the first allene hydrofunctionalization using an synergistic catalysis involving copper

Synthesis of Zirconium Tungstate by Hydrothermal Method

2011 ◽  
Vol 322 ◽  
pp. 201-204
Author(s):  
Li Yun Zheng ◽  
Zhi Wei Yang
Keyword(s):  
Hydrothermal Method ◽  
Negative Thermal Expansion ◽  
Dehydration Reaction ◽  
Large Size ◽  
Thermal Analyzer ◽  
Specific Direction ◽  
Endothermic Process ◽  
Ft Ir ◽  
Hcl Concentration ◽  
Two Stages

Negative thermal expansion material ZrW2O8 was synthesized by hydrothermal method. The prepared ZrW2O8 and the precursor were characterized by x-ray diffractometer, thermo-gravimetric/differential thermal analyzer, FT-IR spectrometer and scanning electron microscope. The results show that a single-phase ZrW2O8 can be synthesized when HCl concentration is as low as 4mol/L. ZrW2O8 was obtained through the precursor dehydration and debonding O-H bond. The dehydration reaction includes two stages. There is a sharp endothermic peak in the first stage of the dehydration reaction and the second stage is a slow endothermic process. A new phase appeared when the sintering temperature is above 600 °C. ZrW2O8 and the precursor have the same rod-like shape and grow up along a specific direction. The synthesized ZrW2O8 particles obtained from 4mol/L HCl appeared large size. It became much finer and the rod with multiple crystal face was easy to form when the concentration of HCl increased to 6~8 mol/L.

Pd-catalyzed tandem homocoupling–aldol–dehydration of ortho-acylphenyl iodides

RSC Advances ◽  
2014 ◽  
Vol 4 (45) ◽  
pp. 23595-23603 ◽  
Author(s):  
Meiqin Fu ◽  
Dongen Lin ◽  
Yuanfu Deng ◽  
Xiao-Qi Zhang ◽  
Yanchu Liu ◽  
...  
Keyword(s):  
Functional Group ◽  
Dehydration Reaction ◽  
Ullmann Coupling

A Pd-catalyzed cascade Ullmann coupling–aldol–dehydration reaction of ortho-acylphenyl iodides affords colchino analogues with wide functional group tolerance.

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones

2016 ◽  
Vol 81 (6) ◽  
pp. 2420-2431 ◽  
Author(s):  
G. Madhusudhan Reddy ◽  
Chi-Ting Ko ◽  
Kai-Hong Hsieh ◽  
Chia-Jui Lee ◽  
Utpal Das ◽  
...  
Keyword(s):  
Primary Amine ◽  
Stereoselective Synthesis ◽  
Amine Catalysis
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