An Oxidative Phenol Coupling Reaction Catalyzed by OxyB, a Cytochrome P450 from the Vancomycin-Producing Microorganism

2004 ◽  
Vol 43 (48) ◽  
pp. 6709-6713 ◽  
Author(s):  
Katja Zerbe ◽  
Katharina Woithe ◽  
Dong Bo Li ◽  
Francesca Vitali ◽  
Laurent Bigler ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Coupling Reaction

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

2016 ◽  
Vol 12 (10) ◽  
pp. 2992-3004 ◽  
Author(s):  
Veronika Ulrich ◽  
Madeleine Peschke ◽  
Clara Brieke ◽  
Max J. Cryle
Keyword(s):  
Cytochrome P450 ◽  
Coupling Reaction ◽  
Glycopeptide Antibiotic

Cytochrome P450 StaH catalyses the first cyclisation reaction in the biosynthesis of the glycopeptide antibiotic A47934 via recruitment to the NRPS machinery through interaction with the X-domain.

scholarly journals Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis

2002 ◽  
Vol 277 (49) ◽  
pp. 47476-47485 ◽  
Author(s):  
Katja Zerbe ◽  
Olena Pylypenko ◽  
Francesca Vitali ◽  
Weiwen Zhang ◽  
Severine Rouset ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Coupling Reaction

scholarly journals Crystal Structure of OxyC, a Cytochrome P450 Implicated in an Oxidative C–C Coupling Reaction during Vancomycin Biosynthesis

2003 ◽  
Vol 278 (47) ◽  
pp. 46727-46733 ◽  
Author(s):  
Olena Pylypenko ◽  
Francesca Vitali ◽  
Katja Zerbe ◽  
John A. Robinson ◽  
Ilme Schlichting
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Coupling Reaction

scholarly journals QM/MM study of the C-C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis

2013 ◽  
Vol 82 (6) ◽  
pp. 1004-1021 ◽  
Author(s):  
Victoria G. Dumas ◽  
Lucas A. Defelipe ◽  
Ariel A. Petruk ◽  
Adrian G. Turjanski ◽  
Marcelo A. Marti
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cytochrome P450 ◽  
Reaction Mechanism ◽  
Coupling Reaction

An Oxidative Phenol Coupling Reaction Catalyzed by OxyB, a Cytochrome P450 from the Vancomycin-Producing Microorganism

2004 ◽  
Vol 116 (48) ◽  
pp. 6877-6881 ◽  
Author(s):  
Katja Zerbe ◽  
Katharina Woithe ◽  
Dong Bo Li ◽  
Francesca Vitali ◽  
Laurent Bigler ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Coupling Reaction

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052457079-8
Author(s):  
Y. Nishiya ◽  
K. Hagihara ◽  
A. Kurihara ◽  
N. Okudaira ◽  
N.A. Farid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19
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