Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

2009 ◽  
Vol 48 (12) ◽  
pp. 2188-2191 ◽  
Author(s):  
Peng Yang ◽  
Anne De Cian ◽  
Marie-Paule Teulade-Fichou ◽  
Jean-Louis Mergny ◽  
David Monchaud
Keyword(s):  
Thiazole Orange ◽  
Quadruplex Dna ◽  
Fluorescent Sensing ◽  
G Quadruplex

Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

2009 ◽  
Vol 121 (12) ◽  
pp. 2222-2225 ◽  
Author(s):  
Peng Yang ◽  
Anne De Cian ◽  
Marie-Paule Teulade-Fichou ◽  
Jean-Louis Mergny ◽  
David Monchaud
Keyword(s):  
Thiazole Orange ◽  
Quadruplex Dna ◽  
Fluorescent Sensing ◽  
G Quadruplex

scholarly journals Lighting Up of Thiazole Orange on G-Quadruplex DNA by High Pressure

ACS Omega ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 4325-4329 ◽  
Author(s):  
Sudipta Bhowmik ◽  
Shuntaro Takahashi ◽  
Naoki Sugimoto
Keyword(s):  
High Pressure ◽  
Thiazole Orange ◽  
Quadruplex Dna ◽  
G Quadruplex

Thiazole Orange Styryl Derivatives as Fluorescent Probes for G-Quadruplex DNA

2020 ◽  
Vol 3 (5) ◽  
pp. 2643-2650 ◽  
Author(s):  
Lingling Zhang ◽  
Xiangjun Liu ◽  
Shanshan Lu ◽  
Jing Liu ◽  
Shilong Zhong ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Thiazole Orange ◽  
Quadruplex Dna ◽  
G Quadruplex

Specific High-Affinity Binding of Thiazole Orange to Triplex and G-Quadruplex DNA

Biochemistry ◽  
2010 ◽  
Vol 49 (17) ◽  
pp. 3567-3574 ◽  
Author(s):  
Irit Lubitz ◽  
Dragoslav Zikich ◽  
Alexander Kotlyar
Keyword(s):  
Affinity Binding ◽  
Thiazole Orange ◽  
High Affinity Binding ◽  
Quadruplex Dna ◽  
High Affinity ◽  
G Quadruplex

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
Sign in / Sign up

Export Citation Format

Share Document